Modulation of corticospinal excitability by paired associative stimulation: Reproducibility of effects and intraindividual reliability
Modulation of corticospinal excitability by paired associative stimulation: Reproducibility of effects and intraindividual reliability
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DOI：
10.1016/j.clinph.2006.07.315
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发表时间：
2006-12-01
影响因子：
4.7
通讯作者：
De Gennaro, Luigi
中科院分区：
文献类型：
--
作者：
Fratello, Fabiana;Veniero, Domenica;De Gennaro, Luigi
目的：电刺激正中神经，然后在初级运动皮层（M1）上施加磁脉冲，可有效地引起目标肌肉中记录的运动诱发电位（MEP）幅度增加，刺激间间期（ISI）为25 ms（配对联想刺激，PAS）。本研究的目的是评估PAS与ISI 25（PAS 25）的再现性，在两个单独的会议进行评估。方法：对18名健康志愿者在PAS25前后进行静息状态下拇短展肌（APB）运动阈值、APB和小指展肌（ADM）MEP波幅的测定（9名男性和9名女性）。数据显示，PAS25后靶肌肉（APB）MEP振幅显著增加，两个疗程的组效应可重复，如ANOVA所评估的，但缺乏个体内的可靠性，如通过组内相关系数（ICC）评估的。结论：结果强调了平均效应的可重复性，并且在不同日期比较同一受试者时需要小心。电刺激正中神经，然后在25 ms后在M1上递送磁脉冲，导致MEP振幅的可再现增加，而没有表现出可接受的个体内可靠性。(c)2006年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Electrical stimulation of the median nerve followed by a magnetic pulse on the primary motor cortex (M1) is effective to cause an increase in the amplitude of motor evoked potential (MEP) registered in the target muscle with the interstimulus interval (ISI) at 25 ms (paired associative stimulation, PAS). The aim of this study is to evaluate the reproducibility of PAS with ISI 25 (PAS25), assessed in two separate sessions. Intraindividual reliability of TMS measures was also evaluated.Methods: Motor threshold of abductor pollicis brevis (APB), assessed at rest, and MEP amplitude of APB and abductor digiti minimi (ADM) were assessed before and after PAS25 in 18 healthy volunteers (nine males and nine females).Results: Data showed a significant increase of MEP amplitude in the target muscle (APB) after PAS25 and a reproducibility of group effect in the two sessions, as assessed by ANOVA, but a lack of intraindividual reliability, as assessed by intraclass correlation coefficients (ICC).Conclusions: The results underline the reproducibility of mean effects and the need to be careful when comparing the same subject on different days.Significance: Electrical stimulation of the median nerve followed by a magnetic pulse delivered on M1 after 25 ms causes a reproducible increase in MEP amplitude, without showing an acceptable intraindividual reliability. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.