Acoustic droplet vaporization for therapeutic and diagnostic applications
Acoustic droplet vaporization for therapeutic and diagnostic applications
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DOI：
10.1016/s0301-5629(00)00262-3
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发表时间：
2000-09-01
影响因子：
2.9
通讯作者：
Carson, PL
中科院分区：
文献类型：
--
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
介绍了一种相移液滴乳剂，用于辅助不寻常的超声（US）应用。通过混合生理盐水、牛白蛋白和十二碳戊烷制备经硫酸钠微滴乳剂（90%直径< 6 μ m）。已经观察到存在声压阈值，高于该声压阈值，液滴蒸发成约为原始直径25倍的气泡。对于1.5和8 MHz之间的频率，阈值从4.5到0.75 MPa的峰值稀疏压力，本文提出了液滴制备和它们的蒸发作为所施加的声压和频率的函数，以及模拟这些气泡的寿命的气体扩散的基础上的初步结果。通过在衰减材料下流动的血液中的液滴的蒸发来模拟体内实验。我们建议，这种代理可能是有用的组织闭塞在癌症治疗中，以及在声学成像相位畸变校正。(C)2000年世界医学和生物学超声联合会。
A phase shift droplet emulsion is introduced as an aid to unusual ultrasound (US) applications. The transpulmonary droplet emulsion (90% < 6 m diameter) is made by mixing saline, bovine albumin and dodecafluoropentane. It has been observed that an acoustic pressure threshold exists, above which the droplets vaporize into bubbles approximately 25 times the original diameter. For frequencies between 1.5 and 8 MHz, the threshold decreases from 4.5 to 0.75 MPa peak rarefactional pressure, This paper presents preliminary results for droplet preparation and their evaporation as a function of applied acoustic pressure and frequency, as well as simulations of the lifetime of these gas bubbles based on gas diffusion. In vivo experiments were simulated by the evaporation of droplets in blood flowing under attenuating material. We propose that this agent might be useful for tissue occlusion in cancer treatment, as well as for phase aberration corrections in acoustic imaging. (C) 2000 World Federation for Ultrasound in Medicine & Biology.