RECEPTIVE-FIELDS AND RESPONSE PROPERTIES OF MECHANORECEPTOR NEURONS INNERVATING SIPHON SKIN AND MANTLE SHELF IN APLYSIA
RECEPTIVE-FIELDS AND RESPONSE PROPERTIES OF MECHANORECEPTOR NEURONS INNERVATING SIPHON SKIN AND MANTLE SHELF IN APLYSIA
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DOI：
10.1152/jn.1974.37.5.1041
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发表时间：
1974-01-01
影响因子：
2.5
通讯作者：
KANDEL, ER
中科院分区：
文献类型：
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作者：
BYRNE, J;CASTELLU.V;KANDEL, ER
在前面的两篇论文中，库普费曼、格鲁和坎德尔（12）以及卡鲁及其同事（5）描述了失眼症中鳃和虹吸回缩反射的运动神经元。这种反射是有趣的，因为它经历了短期和长期的习惯和敏化（4，24，25），可以在细胞水平上详细研究（15）。反射由虹吸管和外套膜架的触觉刺激启动，信息由位于腹神经节中的机械感受器神经元介导（2a，6）。由机械感受神经元形成的中枢突触连接是短期行为改变的关键位点。反射的习惯化和敏感化都是由单突触神经元的功效改变引起的，单突触神经元的功效改变使感觉神经元与鳃和虹吸运动神经元和中间神经元发生联系（6，未发表的数据）。由于感觉神经元在缩鳃反射的行为改变中起着重要作用，因此对该反射的进一步研究需要更好地了解其特性。在本研究中，我们已经检查了机械感受器神经元的感受野和反应特性，以回答以下问题：I）可以识别细胞，特别是对触摸，压力或伤害性刺激的反应？2)感觉神经元的电特性是否不同？如果是，这些差异的功能意义是什么？3)感受野的大小是否与不同感觉器官的感受野大小有关？
IN THE PRECEDING two papers Kupfermann, Grew, and Kandel(12) and Carew and co-workers (5) described motoneurons of the gill-and siphon-withdrawal reflex in ApEysia. This reflex is interesting because it undergoes short-and long-term habituation and sensitization(4, 24, 25) and can be studied in detail at the cellular level (15). The reflex is initiated by tactile stimulation of the siphon and mantle shelf and the information is mediated by mechanoreceptor neurons located in the abdominal ganglion(2a, 6). Central synaptic connections made by the mechanoreceptor neurons serve as critical loci for the short-term behavioral modifications. Both habituation and sensitization of the reflex are paralleled by alterations in the efficacy of the monosynaptic rons ma kccO nnections that the sensory neuonto gill and siphon motoneurons and interneurons(6, and unpublished data). Because the sensory neurons play an important role in the behavioral modifiability of the gill-withdrawal reflex, further studies of this reflex require a better understanding of their properties. Jn the present study we have examined the receptive fields and response properties of the mechanoreceptor neurons in order to answer the following questions: I) Can cells be identified that respond specifically to touch, pressure, or noxious stimuli? 2) Do the sensorv neurons differ in their electrical properties and, if so, what is the functional significance of those differences? 3) Does the size of the receptive field of different sen-