Effects of Chronic Factor VIII Substitution on Immune Parameters in HIV Seronegative Haemophiliacs: a Comparison between Cryoprecipitate and Factor VIII Concentrate
Effects of Chronic Factor VIII Substitution on Immune Parameters in HIV Seronegative Haemophiliacs: a Comparison between Cryoprecipitate and Factor VIII Concentrate
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慢性因子 VIII 替代对 HIV 血清阴性血友病患者免疫参数的影响：冷沉淀与因子 VIII 浓缩物的比较
DOI：
10.1055/s-0038-1650257
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发表时间：
1996
影响因子：
6.7
通讯作者：
E. Briët
中科院分区：
文献类型：
--
作者：
D. Allersmaa;W. Smld;J. A. van der Does;J. van der Meer;E. Briët
总结用因子VIII产品对HIV阴性血友病患者进行慢性替代治疗可导致离体测量的免疫参数异常。为了评估这些异常和产品纯度之间的可能关系，我们分析了两组HIV阴性HCV阳性血友病患者，一组仅用冷沉淀治疗，另一组用更纯化的因子VIII浓缩物治疗。与年龄匹配的未输血男性对照组相比，在两个患者组中均发现白色细胞、粒细胞、IgG和IgM水平增加以及CD 4 +/CD 8+比值降低。在浓缩物接受者中，单个核细胞、CD 4+、CD 8+和CD 3 +/HLA-DR+细胞的数量指示活化的T细胞，高于冷沉淀物组。总之，冷沉淀和中/高纯度浓缩物受体均显示免疫参数异常。这些异常在接受浓缩物治疗的患者中往往更为明显。到目前为止，还没有迹象表明在以前治疗的艾滋病毒血清阴性血友病患者的异常的临床意义。
Summary Chronic substitution therapy of HIV-negative haemophiliacs with factor VIII products can result in abnormalities of ex-vivo measured immune parameters. To assess a possible relation between these abnormalities and product purity, we analyzed two groups of HIV-negative HCV-positive haemophiliacs, one treated with cryoprecipitate exclusively, the other with more purified factor VIII concentrates. Compared to age matched non-transfused male controls, increased numbers of white cells, granulocytes, IgG and IgM levels and decreased CD4+/CD8+ ratios were found in both patient groups. In the concentrate receivers, the numbers of mononuclear cells, CD4+, CD8+ and CD3+/HLA-DR+ cells indicating activated T-cells, were higher than in the cryoprecipitate group. In conclusion, both cryoprecipitate and intermediate/high purity concentrate recipients showed immune parameter abnormalities. These abnormalities tended to be somewhat more pronounced in patients treated with concentrates. By now there is no indication of the clinical relevance of the abnormalities in previously treated HIV seronegative haemophiliacs.