THE PRESSURES IN THE EPISCLERAL VEINS, SCHLEMM CANAL AND THE TRABECULAR MESHWORK IN MONKEYS - EFFECTS OF CHANGES IN INTRAOCULAR-PRESSURE
THE PRESSURES IN THE EPISCLERAL VEINS, SCHLEMM CANAL AND THE TRABECULAR MESHWORK IN MONKEYS - EFFECTS OF CHANGES IN INTRAOCULAR-PRESSURE
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DOI：
10.1016/s0014-4835(89)80060-0
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发表时间：
1989-10-01
影响因子：
3.4
通讯作者：
BILL, A
中科院分区：
文献类型：
--
作者：
MAEPEA, O;BILL, A
本文用针尖直径小于5微米的套管，用显微穿刺法测定了巩膜上静脉、S管和小梁网的压力。施莱姆S管压力为14.3±-。自发性眼压为1.0cmH2O，眼压为19.2+-。0.9cmH2O。前房至S管的流出压为4.9±-。0.7 cmH2O。眼压与眼压的关系为：眼压=0.73PSC+8.7。当眼压从自发水平逐步升高到30cmH2O时，Schlemm‘’S管的眼压升高了1.7cmH2O。0.6cmH2O，(P<；0.05)。总流出阻力和前房与S管之间的阻力为3.27±-。0.43和2.92。+-。0.50cmH2O分·l~(-1)为眼压自发压与高4~11cmH2O水平之间的眼内压区间。在20~30cmH2O的眼压范围内，相应的数值为2.89±-。0.45和2.69。+-。0.42 cmH2O分钟微升-1，压力范围为25-35 cmH2O，2.48+-。0.58和2.31。+-。0.59cmH2O分钟·l-1。当眼压低于35cmH2O时，总流出阻力与前房和Schlemm S管的流出阻力之差约为总流出阻力的10%。在眼压每升高30~50cmH2O期间，眼压逐级升高，小梁网压每升高0.88 cmH2O。总流出阻力和前房与微环尖端之间的阻力为3.91±-。1.53和1.94。+-。自发性眼压与30 cmH2O之间的眼压区间分别为0.99 cmH2O·l-1。在30到45cmH2O之间，相应的数字是2.16+-。0.66和0.20。+-。0.13cmH2O分钟·l-1。自发性眼压时巩膜上静脉压为14.1±-。7只创伤最小的动物为1.0cmH2O，12.3+-。S管插管后动物实验：0.8cmH2O。从前房到巩膜上静脉的流出压为4.4±-。1.2cmH2O，创伤最小的动物，7.1.+-。S管插管后0.8cmH2O。眼压与眼压的关系为：眼压=0.68EVP+11。眼压逐渐升高至50cmH2O时，巩膜上静脉压升高1.5±-。0.4cmH2O(P<；0.05)。结果表明，猴眼约90%的流出阻力位于前房和Schlemm‘’S管之间，50%或以上靠近内壁。管内和巩膜外静脉之间的压力差别不大。眼压的个体间差异很大程度上是由于受体血管内压力的变化。
The pressures in the episcleral veins, Schlemm''s canal and the trabecular meshwork were studied with a micropuncture technique using cannulas with tip diameters of less than 5 .mu.m. The pressure in Schlemm''s canal, Psc, was 14.3 .+-. 1.0 cmH2O at spontaneous intraocular pressure, IOP, 19.2 .+-. 0.9 cmH2O. The outflow pressure from the anterior chamber to Schlemm''s canal was 4.9 .+-. 0.7 cmH2O. The relationship between pressures was IOP = 0.73 Psc +8.7. When the intraocular pressure was increased stepwise for the spontaneous level to 30 cmH2O there was an increase in pressure in Schlemm''s canal of 1.7 .+-. 0.6 cmH2O, (P < 0.05). The total outflow resistance and the resistance between the anterior chamber and Schlemm''s canal were 3.27 .+-. 0.43 and 2.92 .+-. 0.50 cmH2O min .mu.l-1 respectively for the intraocular pressure interval between the spontaneous pressure and a level 4-11 cmH2O higher. In the intraocular pressure range from 20 to 30 cmH2O the corresponding figures were 2.89 .+-. 0.45 and 2.69 .+-. 0.42 cmH2O min .mu.l-1 and for the pressure range 25-35 cmH2O, 2.48 .+-. 0.58 and 2.31 .+-. 0.59 cmH2O min .mu.l-1. The difference between the total outflow resistance and that between the anterior chamber and Schlemm''s canal was about 10% of the total at intraocular pressures below 35 cmH2O. Stepwise increments in IOP increased the trabecular meshwork pressure by 0.88 cmH2O for each cmH2O increase in IOP in the interval of 30-50 cmH2O. The total outflow resistance and the resistance between the anterior chamber and the tip of the microannula was 3.91 .+-. 1.53 and 1.94 .+-. 0.99 cmH2O .mu.l-1 respectively for the intraocular pressure interval between the spontaneous pressure and 30 cmH2O. In the interval between 30 and 45 cmH2O the corresponding figures were 2.16 .+-. 0.66 and 0.20 .+-. 0.13 cmH2O min .mu.l-1. The episcleral venous pressure at the spontaneous intraocular pressure was 14.1 .+-. 1.0 cmH2O in seven animals with minimal trauma, and 12.3 .+-. 0.8 cmH2O in animals after cannulation of Schlemm''s canal. The outflow pressure from the anterior chamber to the episcleral veins was 4.4 .+-. 1.2 cmH2O in animals with minimal trauma and 7.1 .+-. 0.8 cmH2O after cannulation of Schlemma''s cannal. The relationship between pressures was IOP = 0.68EVP + 11. Stepwise increases in IOP to 50 cmH2O caused a rise in episcleral venous pressure of 1.5 .+-. 0.4 cmH2O (P < 0.05). The results indicate that about 90% of the outflow resistance in monkey eyes is located between the anterior chamber and Schlemm''s canal, 50% or more being near to the inner wall. There is little difference in pressure between the canal and the episcleral veins. Much of the interindividual variability in IOP was due to variations in pressure in the recipient vessels.