Structure, production and signaling of leptin.
Structure, production and signaling of leptin.
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DOI：
10.1016/j.metabol.2014.09.010
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发表时间：
2015-01
影响因子：
9.8
通讯作者：
Morrison, Christopher D.
中科院分区：
文献类型：
--
作者：
Muenzberg, Heike;Morrison, Christopher D.
1994年瘦素基因的克隆是肥胖研究的一个重要里程碑。在那些日子里，肥胖被认为是由于缺乏个性和自制力而导致的一种疾病。瘦素或其受体的突变是第一个被发现的导致病态肥胖的单基因突变，现在人们认识到肥胖是由中枢神经回路的失调引起的。从瘦素缺乏型肥胖小鼠(ob/ob)的首次发现，到瘦素(ob又称lep)和瘦素受体(db又称lepr)基因的克隆，人们对瘦素及其在中枢神经系统中的作用有了许多了解。人们最初对瘦素可以治愈肥胖症抱有很高的希望，但很快就被发现破灭了，因为大多数肥胖者的瘦素水平都增加了，并产生了瘦素抵抗。然而，大脑中的瘦素靶点为控制能量动态平衡的不同神经元回路提供了一个很好的蓝图。更好地了解这些回路的调节和相互连接将进一步指导和改进安全有效的干预措施的发展，以治疗肥胖。这篇综述将强调我们目前对激素瘦素的了解，它的信号通路以及它在调节不同生理功能中的中心作用。
The cloning of leptin in 1994 was an important milestone in obesity research. In those days obesity was stigmatized as a condition caused by lack of character and self-control. Mutations in either leptin or its receptor were the first single gene mutations found to cause morbid obesity, and it is now appreciated that obesity is caused by a dysregulation of central neuronal circuits. From the first discovery of the leptin deficient obese mouse (ob/ob), to the cloning of leptin (ob aka lep) and leptin receptor (db aka lepr) genes, much has been learned about leptin and its action in the central nervous system. The initial high hopes that leptin would cure obesity were quickly dampened by the discovery that most obese humans have increased leptin levels and develop leptin resistance. Nevertheless, leptin target sites in the brain represent an excellent blueprint for distinct neuronal circuits that control energy homeostasis. A better understanding of the regulation and interconnection of these circuits will further guide and improve the development of safe and effective interventions to treat obesity. This review will highlight our current knowledge about the hormone leptin, its signaling pathways and its central actions to mediate distinct physiological functions.
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影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
影响因子：
29
作者：
Balland E;Dam J;Langlet F;Caron E;Steculorum S;Messina A;Rasika S;Falluel-Morel A;Anouar Y;Dehouck B;Trinquet E;Jockers R;Bouret SG;Prévot V
通讯作者：
Prévot V
DOI：
10.1152/ajpregu.00179.2014
发表时间：
2014-08-15
影响因子：
2.8
作者：
Alhadeff, Amber L.;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
影响因子：
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作者：
Argetsinger, Lawrence S.;Stuckey, Jeanne A.;Carter-Su, Christin
通讯作者：
Carter-Su, Christin
影响因子：
29
作者：
Chao PT;Yang L;Aja S;Moran TH;Bi S
通讯作者：
Bi S