ANXIOLYTIC-LIKE EFFECTS OF ALPHA-2-ADRENOCEPTOR AGONISTS ON CONFLICT BEHAVIOR IN THE RAT - PRESYNAPTIC VERSUS POSTSYNAPTIC RECEPTOR MECHANISMS
ANXIOLYTIC-LIKE EFFECTS OF ALPHA-2-ADRENOCEPTOR AGONISTS ON CONFLICT BEHAVIOR IN THE RAT - PRESYNAPTIC VERSUS POSTSYNAPTIC RECEPTOR MECHANISMS
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DOI：
10.1016/0091-3057(92)90398-y
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发表时间：
1992-11-01
影响因子：
3.6
通讯作者：
COMMISSARIS, RL
中科院分区：
文献类型：
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作者：
FONTANA, DJ;COMMISSARIS, RL
研究了可乐定或选择性α_2-肾上腺素能受体激动剂UK-14，304对冲突行为的影响。在每天10分钟的训练中，缺水的大鼠被训练从偶尔通电（0.25 mA）的管子中喝水;通过音调发出通电信号。在治疗前，受试者接受25-30次电击/疗程（惩罚性反应），并消耗约12-15 ml/疗程（未惩罚性反应）。可乐定或UK-14，304的急性试验前管理并没有增加惩罚性反应。与此相反，慢性试验后可乐定给药（40 μ g/kg，IP，每天两次，持续8周）导致相对于生理盐水处理的对照组，惩罚反应（60-70次电击/会话）的稳健和时间依赖性增加。此外，选择性α 2-肾上腺素受体激动剂UK-14，304在长期给药（1.0 mg/kg，BID）时也增加了惩罚性反应。去甲肾上腺素能神经毒素N-（2-氯乙基）-N-乙基-2-溴苄胺盐酸盐（DSP 4，65 mg/kg，IP）的管理显着降低惩罚反应在控制条件性抑制饮酒会议。抗冲突的效果与慢性试验后可乐定治疗没有改变DSP 4预处理。这些发现表明，慢性试验后α 2-肾上腺素受体激动剂治疗产生的抗冲突的影响，其行动独立于突触前α 2-肾上腺素受体。
The effects of acute pretest administration and chronic posttest administration of clonidine or the selective alpha2-adrenoceptor agonist UK-14,304 on conflict behavior were investigated. In daily 10-min sessions, water-deprived rats were trained to drink water from a tube that was occasionally electrified (0.25 mA); electrification was signaled by a tone. Prior to treatment, subjects accepted 25-30 shocks/session (punished responding) and consumed approximately 12-15 ml/session (unpunished responding). Acute pretest administration of clonidine or UK-14,304 did not increase punished responding. In contrast, chronic posttest clonidine administration (40 mug/kg, IP, twice daily for 8 weeks) resulted in a robust and time-dependent increase in punished responding (60-70 shocks/session) relative to saline-treated controls. Moreover, the selective alpha2-adrenoceptor agonist UK-14,304 also increased punished responding when administered chronically (1.0 mg/kg, BID). Administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine HCI (DSP4, 65 mg/kg, IP) significantly decreased punished responding in control conditioned suppression of drinking sessions. The anticonflict effect associated with chronic posttest clonidine treatment was not altered by DSP4 pretreatment. These findings suggest that chronic posttest alpha2-adrenoceptor agonist treatment produces an anticonflict effect independent of its actions at presynaptic alpha2-adrenoceptors.