Importance of collaboration of dermatology and rheumatology to advance the field for lupus and dermatomyositis.
Importance of collaboration of dermatology and rheumatology to advance the field for lupus and dermatomyositis.
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DOI：
10.1016/j.ijwd.2021.09.002
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发表时间：
2021-12
影响因子：
--
通讯作者：
Lundberg IE
中科院分区：
文献类型：
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作者：
Werth VP;Askanase AD;Lundberg IE
对皮肤狼疮和皮肌炎的临床和转化理解取得了许多进展，这两种疾病对女性的影响尤其严重。这些进展涉及皮肤病学和风湿病学之间的持续合作，强调了皮肤在这些疾病中的重要性，并改善了学员的教育和这些复杂的多系统疾病的临床管理。此外，新的疾病分类允许将皮肤为主的皮肌炎患者纳入特发性炎症性肌病谱中，这些患者通常与全身症状相关。经过验证的结果测量可以实现转化研究，并促进更好、更有针对性的治疗方法的进展。使用疾病严重程度工具（例如皮肤红斑狼疮面积和严重程度指数以及皮肤皮肌炎疾病面积和严重程度指数）的临床试验可以测量皮肤的改善情况。最近的 2 期和 3 期试验结果清楚地表明，患者将受益于皮肤病学和风湿病学之间的协作互动和研究。
There have been a number of advances in the clinical and translational understanding of cutaneous lupus and dermatomyositis, which both disproportionately affect women. These advances have involved ongoing collaborations between dermatology and rheumatology that highlight the importance of the skin in these disorders, with improvement in the education of trainees and clinical management of these complex multisystem diseases. In addition, a new disease classification has allowed inclusion of patients with skin-predominant dermatomyositis, frequently associated with systemic findings, in the spectrum of idiopathic inflammatory myopathies. Validated outcome measures allow translational research and facilitate progress toward better and more targeted therapeutics. Clinical trials using disease severity tools, such as the Cutaneous Lupus Erythematosus Area and Severity Index and the Cutaneous Dermatomyositis Disease Area and Severity Index, allow measurement of improvement in the skin. Recent results of phase 2 and 3 trials clearly show that patients will benefit from collaborative interactions and studies between dermatology and rheumatology.