Flow and myocardial interaction: an imaging perspective
Flow and myocardial interaction: an imaging perspective
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血流和心肌相互作用：成像视角
DOI：
10.1098/rstb.2007.2119
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
P. Kilner
中科院分区：
文献类型：
--
作者：
Guang;R. Merrifield;S. Masood;P. Kilner
冠状动脉疾病引起的心力衰竭具有相当高的发病率和较差的预后。了解控制心肌收缩的基本机制是解释和预测心脏病引起的变化的先决条件。利用现有技术可以容易地检测到心肌收缩行为的总体变化。然而，对于心脏功能障碍早期阶段更微妙的变化，需要一种灵敏的测量方法以及量化正常和受损心肌功能的精确标准。本文的目的是概述成像技术，特别是心血管磁共振 (CMR) 在研究心脏形态、功能和血流之间的基本关系方面的作用。 CMR 因其安全性、多功能性和生成的高质量图像而成为一种重要的临床工具，可以准确且可重复地量化心脏结构和功能。我们展示了如何通过 CMR 实现心脏的形态和功能评估，并说明如何使用血流成像来研究血流和结构相互作用，特别是阐明心脏循环的方向变化和不对称性的潜在血流动力学意义。还提供了在特定主题的生物力学模拟中将成像与工程方法相结合的未来展望。
Heart failure due to coronary artery disease has considerable morbidity and poor prognosis. An understanding of the underlying mechanics governing myocardial contraction is a prerequisite for interpreting and predicting changes induced by heart disease. Gross changes in contractile behaviour of the myocardium are readily detected with existing techniques. For more subtle changes during early stages of cardiac dysfunction, however, a sensitive method for measuring, as well as a precise criterion for quantifying, normal and impaired myocardial function is required. The purpose of this paper is to outline the role of imaging, particularly cardiovascular magnetic resonance (CMR), for investigating the fundamental relationships between cardiac morphology, function and flow. CMR is emerging as an important clinical tool owing to its safety, versatility and the high-quality images it produces that allow accurate and reproducible quantification of cardiac structure and function. We demonstrate how morphological and functional assessment of the heart can be achieved by CMR and illustrate how blood flow imaging can be used to study flow and structure interaction, particularly for elucidating the underlying haemodynamic significance of directional changes and asymmetries of the cardiac looping. Future outlook on combining imaging with engineering approaches in subject-specific biomechanical simulation is also provided.
DOI：
10.1016/0735-1097(92)90314-d
发表时间：
1992-05-01
影响因子：
24
作者：
MITCHELL, GF;LAMAS, GA;PFEFFER, MA
通讯作者：
PFEFFER, MA
DOI：
10.1115/1.1427042
发表时间：
2002-02-01
影响因子：
1.7
作者：
Stroud, JS;Berger, SA;Saloner, D
通讯作者：
Saloner, D