Brain tissue volume changes following weight gain in adults with anorexia nervosa.
Brain tissue volume changes following weight gain in adults with anorexia nervosa.
复制标题
神经性厌食症成人体重增加后脑组织体积发生变化。
DOI：
10.1002/eat.20840
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Walsh,BTimothy
中科院分区：
文献类型：
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作者：
Roberto,ChristinaA;Mayer,LaurelES;Brickman,AdamM;Barnes,Anna;Muraskin,Jordan;Yeung,Lok-Kin;Steffener,Jason;Sy,Melissa;Hirsch,Joy;Stern,Yaakov;Walsh,BTimothy
目的测量体重不足的神经性厌食症(AN)患者与对照组相比的脑体积缺陷，并评价短期体重恢复后这些缺陷的可逆性。方法检测32例患有AN的成年女性和21名年龄和体重指数范围匹配的对照组的脑灰质(GM)、白质(WM)和脑脊液(CSF)的脑体积变化。结果AN患者在体重恢复后GM(p=0.006，η2=0.14)和WM体积(p=.001，η2=0.19)显著增加。低体重AN患者的GM平均水平(647.63±62.07ml)低于对照组(679.93±53.31ml)，后者随体重恢复(662.64±69.71ml)而升高，但未完全恢复正常。2010Wiley期刊公司(INT J Eat Disord 2011；44：406-411)
ObjectiveTo measure brain volume deficits among underweight patients with anorexia nervosa (AN) compared to control participants and evaluate the reversibility of these deficits with short‐term weight restoration.MethodBrain volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined in 32 adult women with AN and compared to 21, age and body mass index‐range matched control women.ResultsPatients with AN had a significant increase in GM (p= .006, η2= 0.14) and WM volume (p= .001, η2= 0.19) following weight restoration. Patients on average had lower levels of GM at low weight (647.63 ± 62.07 ml) compared to controls (679.93 ± 53.31 ml), which increased with weight restoration (662.64 ± 69.71 ml), but did not fully normalize.DiscussionThis study suggests that underweight adult patients with AN have reduced GM and WM volumes that increase with short‐term weight restoration. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:406–411)