Temporal evolution of oscillations and synchrony in GPi/muscle pairs in Parkinson's disease
Temporal evolution of oscillations and synchrony in GPi/muscle pairs in Parkinson's disease
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DOI：
10.1152/jn.00829.2004
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发表时间：
2005-03-01
影响因子：
2.5
通讯作者：
Pappas, CTE
中科院分区：
文献类型：
--
作者：
Hurtado, JA;Rubchinsky, LL;Pappas, CTE
标准频谱分析和时间依赖性相位相关技术应用于27对震颤相关的单一单位在苍白球内（GPi）和肌电图的帕金森病（PD）患者接受立体定向神经外科手术。在较长的时间尺度上（类似于60秒），GPi震颤相关单位与显示震颤的外周肌肉组织的限制区域在统计学上是一致的。所有对的汇集一致性的分布支持GPi细胞/EMG振荡对的分类为一致性或非一致性。使用类似于2-s滑动窗口的分析表明，GPi震颤单位和肌肉中的振荡活动随着时间的推移间歇性地发生。对于大脑/肌肉对是连贯的。在振荡活动的时间上存在部分重叠，但是。在大多数情况下，两个信号中振荡子脉冲的时间之间没有显著的相关性。相干对之间的相位锁定是瞬时发生的，然而，对于不同的相位锁定子相位，相位延迟是相似的。非相干对也表现出短暂的相位锁定的情节，但他们发生的频率较低，并没有首选的相位延迟被视为整个subepatide。苍白球和肌电图中的震颤振荡被相位滑移打断，相位滑移根据其对相位锁定的影响被分类为同步或去同步。在相干对中，同步滑移的发生率高于去同步滑移。而对于非相干对没有观察到显著差异。帕金森氏震颤的定量表征的结果提供了一个基础的假设的结构和动力学功能的基底神经节运动控制网络参与震颤的产生。
Both standard spectral analysis and time-dependent phase correlation techniques were applied to 27 pairs of tremor-related single units in the globus pallidus internus (GPi) and EMG of patients with Parkinson's disease (PD) undergoing stereotactic neurosurgery. Over long time-scales (similar to60 s), GPi tremor-related units were statistically coherent with restricted regions of the peripheral musculature displaying tremor. The distribution of pooled coherence across all pairs supports a classification of GPi cell/EMG oscillatory pairs into coherent or noncoherent. Analysis using similar to2-s sliding windows shows that oscillatory activity in both GPi tremor units and muscles occurs intermittently over time. For brain/muscle pairs that are coherent. there is partial overlap in the times of oscillatory activity but. in most cases, no significant correlation between the times of oscillatory subepisodes in the two signals. Phase locking between coherent pairs occurs transiently; however, the phase delay is similar for different phase-locking subepisodes. Noncoherent pairs also show episodes of transient phase locking, but they occurred less frequently, and no preferred phase delay was seen across subepisodes. Tremor oscillations in pallidum and EMGs are punctuated by phase slips, which were classified as synchronizing or desynchronizing depending on their effect on phase locking. In coherent pairs, the incidence of synchronizing slips is higher than desynchronizing slips. whereas no significant difference was seen for noncoherent pairs. The results of this quantitative characterization of parkinsonian tremor provide a foundation for hypotheses about the structure and dynamical functioning of basal ganglia motor control networks involved in tremor generation.