Set Shifting in a Rodent Model of Attention-Deficit/Hyperactivity Disorder
Set Shifting in a Rodent Model of Attention-Deficit/Hyperactivity Disorder
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DOI：
10.1037/a0023571
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发表时间：
2011-06-01
影响因子：
1.9
通讯作者：
Green, John T.
中科院分区：
文献类型：
--
作者：
Chess, Amy C.;Raymond, Brittany E.;Green, John T.
两个实验比较了自发性高血压大鼠(SHR；注意力缺陷/多动障碍的啮齿动物模型)和Wistar大鼠(正常活动对照品系)在获得定势转移策略方面的差异。在实验1中，SHR和Wistar大鼠在学习亮度或纹理辨别的标准的实验中是相同的，但当初始辨别和纹理辨别之间有1到2天的时间时，SHR比Wistar大鼠更快地转移到相反的辨别。在实验2中，SHR和Wistar大鼠在第一次辨别中满足标准后立即发生辨别之间的转移时，在转移方面是相同的。根据SRS未能存储或检索延迟上的初始区分和/或潜在抑制来讨论结果，从而导致更快地获取SET-Shift。这种储存或提取的失败可能是由于SHR前额叶皮质和伏隔核外壳的多巴胺系统活性低下以及内嗅皮层的异常所致。
Two experiments compared spontaneously hypertensive rats (SHRs; a rodent model of attention-deficit/hyperactivity disorder) and Wistar rats (a normoactive control strain), on the acquisition of a set-shifting strategy. In Experiment 1, SHRs and Wistar rats were equivalent in trials to criterion to learn a brightness or a texture discrimination but SHRs were faster than Wistar rats in shifting to the opposite discrimination when there was 1 or 2 days between the initial discrimination and the shift. In Experiment 2, SHRs and Wistar rats were equivalent in shifting when the shift between discriminations occurred immediately after a criterion had been met in the first discrimination. The results are discussed in terms of a failure of SHRs to store or retrieve an initial discrimination and/or latent inhibition over a delay, leading to faster acquisition of a set-shift. This failure in storage or retrieval may be the result of a hypoactive dopamine system in the prefrontal cortex and nucleus accumbens shell as well as abnormalities in entorhinal cortex in SHRs.