SWITCHING NEURONS ARE INTEGRAL MEMBERS OF MULTIPLE OSCILLATORY NETWORKS
SWITCHING NEURONS ARE INTEGRAL MEMBERS OF MULTIPLE OSCILLATORY NETWORKS
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DOI：
10.1016/s0960-9822(00)00199-8
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发表时间：
1994-10-01
期刊：
影响因子：
9.2
通讯作者：
MARDER, E
中科院分区：
文献类型：
--
作者：
WEIMANN, JM;MARDER, E
背景资料：蟹的口胃神经节包含产生几种不同行为的神经元，例如快速幽门节律和较慢的胃磨节律。先前已经表明，许多口胃神经节神经元可以在幽门定时活动和胃定时活动之间切换。然而，问题仍然存在，这些神经元是否真的是几个中央模式生成网络的组成成员，或者只是被动的追随者聊天只改变他们的活动模式，在响应由其他neurons.Results确定的开关：为了解决这个问题，我们扰动的“幽门”心室扩张神经元和“胃”侧胃神经元的活动在进行中的幽门和胃的节奏。在没有持续的胃节律的情况下，这些神经元可以在幽门时间内放电，扰乱它们可以重置幽门节律。在强大的胃活动，胃侧和心室扩张神经元可以发射在胃的时间，扰乱他们可以重置胃rhythm.Conclusions：当口胃神经节神经元改变他们的发射模式，他们也作为电路的一部分，产生新的节奏，他们正在发射，表明单个神经元可以被用来作为多个模式生成电路的一部分。
Background: The stomatogastric ganglion of the crab Canter borealis contains the neurons that generate several different behaviors, such as the fast pyloric rhythm and the slower gastric-mill rhythm. It has previously been shown that many stomatogastric ganglion neurons can switch between pyloric- and gastric-timed activity. However, the question remained whether these neurons really are integral members of several central-pattern-generating networks, or just passive followers chat only change their activity patterns in response to a switch determined by other neurons.Results: To address this question, we perturbed the activity of the 'pyloric' ventricular dilator neuron and the 'gastric' lateral gastric neuron during ongoing pyloric and gastric rhythms. In the absence of ongoing gastric rhythms, these neurons can fire in pyloric time, and perturbing them can reset the pyloric rhythm. During robust gastric activity, the lateral gastric and ventricular dilator neurons can fire in gastric time, and perturbing them can reset the gastric rhythm.Conclusions: When stomatogastric ganglion neurons change their firing patterns, they also function as part of the circuitry that generates the new rhythm with which they are firing, demonstrating that individual neurons can be used as part of multiple pattern-generating circuits.