Diabetes mellitus and the incidence of hip fracture:: results from the Nord-Trondelag Health Survey
Diabetes mellitus and the incidence of hip fracture:: results from the Nord-Trondelag Health Survey
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DOI：
10.1007/s001250051248
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发表时间：
1999-08-01
期刊：
影响因子：
8.2
通讯作者：
Edna, TH
中科院分区：
文献类型：
--
作者：
Forsén, L;Meyer, HE;Edna, TH
目的/假说。研究I型（胰岛素依赖型）或II型（非胰岛素依赖型）糖尿病患者髋部骨折的风险是否增加。研究人群包括35 444名50岁及以上的人，他们在挪威的一个县参加了健康检查。随访9年，新增髋部骨折1643例。经年龄、体重指数和每日吸烟调整后，1型糖尿病女性髋部骨折的相对危险度为6.9（95%可信区间2.2-21.6）。男性的相对风险几乎相同，但没有统计学意义。在50-74岁2型糖尿病患者超过5年的女性中，相对危险度为1.8（95%可信区间为1.1-2.9）。当接受胰岛素治疗的女性被排除在分析之外时，这种增加的风险仍然存在。在对糖尿病可能的医疗后果（视力受损、运动能力受损和卒中史）进行额外调整后，50-75岁患有II型糖尿病的女性的相对风险降至1.5（95%置信区间0.9-2.5）。结论/解释。我们发现，年龄小于75岁的女性I型糖尿病患者或长期II型糖尿病患者髋部骨折的风险增加。在老年男性中，与持续时间较短的II型糖尿病相关的风险增加。风险增加是由于骨量减少还是与跌倒有关的因素尚未确定。
Aims/hypothesis. To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture.Methods. The study population consisted of 35 444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with respect to hip fracture for 9 years, and 1643 new hip fractures were recorded.Results. The relative risk of hip fracture for women with Type I diabetes compared with women without diabetes was 6.9 (95 % confidence interval 2.2-21.6) adjusted for age, body mass index and daily smoking. The relative risk for men was nearly the same, but not statistically significant. Among women 50-74 years of age with Type II diabetes for more than 5 years, the relative risk was 1.8 (95% confidence interval 1.1-2.9). This increased risk persisted when insulin-treated women were excluded from the analysis. After additional adjustment for possible medical consequences of diabetes (impaired vision, impaired motor abilities and history of stroke) the relative risk among women 50-75 years of age with Type II diabetes was reduced to 1.5 (95 % confidence interval 0.9-2.5).Conclusion/interpretation . We found an increased risk of hip fracture in women younger than 75 years with Type I diabetes or with Type II diabetes of long duration. In older men, there was an increased risk associated with Type II diabetes of shorter duration. Whether the increased risk is attributed to reduced bone mass or to factors associated with falling has not been determined.