Magnetic resonance imaging during dobutamine stress in coronary artery disease.
Magnetic resonance imaging during dobutamine stress in coronary artery disease.
复制标题
冠状动脉疾病多巴酚丁胺应激期间的磁共振成像。
DOI：
10.1016/0002-9149(92)91386-i
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Longmore
中科院分区：
文献类型：
--
作者：
D. Pennell;S. Underwood;C. Manzara;R. Swanton;J. Walker;P. Ell;D. Longmore
Cine magnetic resonance imaging (MRI) provides a tomographic method of assessing regional ventricular function in any desired plane. It has not been possible to obtain adequate images during dynamic exercise, and this has limited its value in patients with coronary artery disease (CAD). Therefore, an infusion of dobutamine was used to study 25 patients with exertional chest pain and abnormal exercise electrocardiograms. Areas of abnormal wall motion were compared with areas of abnormal myocardial perfusion imaged by dobutamine thallium emission tomography and with coronary arteriography. Twenty-two patients had significant CAD. Twenty-one (96%) of these patients had reversible myocardial ischemia shown by dobutamine thallium tomography, and 20 (91%) had reversible wall motion abnormalities shown by dobutamine MRI. Comparison of abnormal segments of perfusion and wall motion showed 96% agreement at rest, 90% agreement during stress, and 91% agreement for the assessment of functional reversibility. The normalized magnetic resonance signal intensity of the ischemic segments showed a small but significant reduction when compared with that of normal segments (−67 units [9.2%]; p < 0.05). Dobutamine infusion was well-tolerated, despite causing chest discomfort in 24 patients (96%). Nine patients (36%) developed a minor dysrhythmia that was usually ventricular premature complexes, but this did not limit infusion, and other side effects were mild. The short plasma half-life of dobutamine makes it ideal as a stress agent for imaging techniques (such as MRI), and these results suggest that it is more effective in the provocation of wall motion abnormalities than is dipyridamole in patients with CAD.
多巴酚丁胺与双嘧达莫应激干预在严重冠状动脉狭窄评估中的生理学基础。
影响因子：
37.8
作者：
Fung,AY;Gallagher,KP;Buda,AJ
通讯作者：
Buda,AJ
心脏手术后的多巴酚丁胺和多巴胺：多巴酚丁胺可更大程度地增加心肌血流量。
影响因子：
37.8
作者：
Fowler,MB;Alderman,EL;Oesterle,SN;Derby,G;Daughters,GT;Stinson,EB;Ingels,NB;Mitchell,RS;Miller,DC
通讯作者：
Miller,DC