Kasabach-Merritt syndrome: Identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61
Kasabach-Merritt syndrome: Identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61
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DOI：
10.1046/j.1525-1470.1999.00103.x
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发表时间：
1999-09-01
影响因子：
1.5
通讯作者：
Sohn, KR
中科院分区：
文献类型：
--
作者：
Seo, SK;Suh, JC;Sohn, KR
Kasabach-Merritt综合征(KMS)是一种巨大且生长迅速的血管肿瘤，与血小板减少、泛发性瘀点和出血有关。血小板减少的原因被认为与肿瘤异常内皮细胞对血小板的捕获有关。我们报告一例伴有大的簇状血管瘤的KMS婴儿。在这个病例中，我们使用抗CD61的单抗，通过免疫组织化学技术，直接证明了血小板在肿瘤的血管腔内被捕获。CD61是血小板和巨核细胞的标志。
Kasabach-Merritt syndrome (KMS) consists of large and rapidly growing vascular tumors associated with thrombocytopenia, generalized petechiae, and bleeding. The cause of the thrombocytopenia is thought to be related to the trapping of platelets by the abnormal endothelium of the tumor, We report an infant with KMS that developed in association with a large tufted angioma. In this case we directly demonstrated platelet trapping in the vascular lumen of the tumor by an immunohistochemical technique using a monoclonal antibody against CD61, a marker of platelets and megakaryocytes.