Prevalence of restless legs syndrome with pregnancy and the relationship with sleep disorders in the Japanese large population
Prevalence of restless legs syndrome with pregnancy and the relationship with sleep disorders in the Japanese large population
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DOI：
10.1111/j.1479-8425.2008.00343.x
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发表时间：
2008-04-01
影响因子：
1.1
通讯作者：
Hayashi, Kenji
中科院分区：
文献类型：
--
作者：
Harano, Satoru;Hida, Takashi;Hayashi, Kenji
本研究基于国际不宁腿综合征研究组（IRLSSG）的诊断标准，重新检查了日本孕妇中不宁腿综合征（RLS）的患病率，并从流行病学上阐明了与RLS相关的因素，包括睡眠障碍和妊娠状态。在日本的344个临床产科机构进行了横断面调查。共有19，441名确诊怀孕的女性被要求在等待咨询期间完成一份自我管理的问卷。采用单因素和多因素Logistic回归分析。女性中RLS的患病率为2.9%。各年龄组的患病率呈U型曲线，30多岁的患病率最低。在怀孕的第三个三个月，患病率高出两倍多。RLS与妊娠晚期、经产妇、吸烟、主观睡眠不足、入睡困难、早醒和白天过度嗜睡之间有较强的相关性（OR分别为1.92、0.76、1.54、1.68、2.44、1.80、1.89）。日本孕妇中RLS的患病率不像以前报道的那样高，与日本普通人群相似。由于RLS的患病率低于西方国家，遗传背景可能比怀孕对观察到的差异有更大的贡献。在这项研究中，与其他研究一样，RLS的患病率在妊娠晚期增加，并且观察到RLS与入睡困难之间以及RLS与维持睡眠困难之间存在强相关性。
This study re-examined the prevalence of restless legs syndrome (RLS) among pregnant women in Japan based on the diagnostic criteria of the International Restless Legs Syndrome Study Group (IRLSSG), and to epidemiologically clarify factors associated with RLS, including sleep disorders and pregnancy status. A cross-sectional survey was conducted at 344 clinical obstetric institutions in Japan. A total of 19 441 women with a confirmed pregnancy were instructed to complete a self-administered questionnaire during the time they spent waiting for a consultation. univariate and multiple logistic regression analyses were used. The prevalence of RLS among the women was 2.9%. The prevalence by age group exhibited a U-shaped curve with the value for those in their thirties as the minimum. The prevalence became more than twice higher in the third trimester of pregnancy. There were stronger associations between RLS and the third trimester of pregnancy, multipara, smoking, subjective insufficient sleep, difficulty initiating sleep, early morning awakening and excessive daytime sleepiness (OR: 1.92, 0.76, 1.54, 1.68, 2.44, 1.80, 1.89, respectively). The prevalence of RLS among pregnant women in Japan was not as high as previously reported, similar to that for the general Japanese population. As the prevalence of RLS is lower than that in Western countries, genetic backgrounds may contribute more to the observed differences than pregnancy does. in this study, like others, the prevalence of RLS increased during the third trimester of pregnancy, and strong associations were observed between RLS and difficulty initiating sleep and between RLS and difficulty maintaining sleep.