Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults The Cardiovascular Health Study
Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults The Cardiovascular Health Study
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DOI：
10.1093/aje/kwac044
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发表时间：
2022-03-08
影响因子：
5
通讯作者：
Kizer, Jorge R.
中科院分区：
文献类型：
--
作者：
Shitole, Sanyog G.;Biggs, Mary L.;Kizer, Jorge R.
为了评价非酯化脂肪酸（NEFA）与老年人血脂异常的关系，在心血管健康研究（美国，1989-1993年入组）的参与者中测量了NEFA水平。与胰岛素敏感性和胰腺β细胞功能，并与2型糖尿病（DM）的事件，进行了检查。样本包括2，144名参与者（年龄77.9（标准差，4.5）岁）。使用1996-1997年心血管健康研究访视的参与者数据，前瞻性随访至2010年。空腹和后负荷NEFA显示出显著的相关性，降低胰岛素敏感性和胰腺β细胞功能，单独和同时调整。在中位随访9.7年期间，发生了236例DM。负荷后NEFA与DM风险相关（根据标准差，风险比= 1.18，95%置信区间：1.08，1.29），但空腹NEFA与DM风险无关（风险比= 1.12，95%置信区间：0.97，1.29）。在调整了假定的中间体和空腹NEFA后，负荷后NEFA的相关性仍然存在。性别和体重指数改变了这些相关性，在男性中，空腹NEFA与DM的相关性更强，但在女性和较瘦的个体中，空腹NEFA与DM的相关性更强。空腹和负荷后NEFA与较低的胰岛素敏感性和胰腺β细胞功能相关，但只有负荷后NEFA与DM增加相关。对NEFA代谢的进一步研究可能会发现老年人糖尿病预防的新潜在目标。
To evaluate the association of nonesterified fatty acids (NEFA) with dysglycemia in older adults, NEFA levels were measured among participants in the Cardiovascular Health Study (United States; enrolled 1989-1993). Associations with insulin sensitivity and pancreatic beta-cell function, and with incident type 2 diabetes mellitus (DM), were examined. The sample comprised 2,144 participants (aged 77.9 (standard deviation, 4.5) years). Participant data from the Cardiovascular Health Study visit in 1996-1997 was used with prospective follow-up through 2010. Fasting and postload NEFA showed significant associations with lower insulin sensitivity and pancreatic beta-cell function, individually and on concurrent adjustment. Over median follow-up of 9.7 years, 236 cases of DM occurred. Postload NEFA were associated with risk of DM (per standard deviation, hazard ratio = 1.18, 95% confidence interval: 1.08, 1.29), but fasting NEFA were not (hazard ratio = 1.12, 95% confidence interval: 0.97, 1.29). The association for postload NEFA persisted after adjustment for putative intermediates, and after adjustment for fasting NEFA. Sex and body mass index modified these associations, which were stronger for fasting NEFA with DM in men but were accentuated for postload NEFA in women and among leaner individuals. Fasting and postload NEFA were related to lower insulin sensitivity and pancreatic beta-cell function, but only postload NEFA were associated with increased DM. Additional study into NEFA metabolism could uncover novel potential targets for diabetes prevention in elders.