Plasma selenium levels and the risk of colorectal adenomas
Plasma selenium levels and the risk of colorectal adenomas
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DOI：
10.1080/01635589709514563
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发表时间：
1997-01-01
影响因子：
2.9
通讯作者：
Sandler, RS
中科院分区：
文献类型：
--
作者：
Russo, MW;Murray, SC;Sandler, RS
先前的研究表明，硒可以预防结直肠肿瘤的发生。我们在控制一些饮食和生活方式因素的情况下，研究了硒对结直肠腺瘤的潜在化学预防特性。我们对到北卡罗来纳大学医院进行结肠镜检查的患者进行了横断面研究。病例有一个或多个病理证实的腺瘤，而非病例无。采用塞曼背景校正和平台技术的石墨炉原子吸收光谱法测定血浆硒水平。比值比计算采用逻辑回归分析调整潜在的混杂因素。病例（n = 37）和非病例（n = 36）的平均血浆硒浓度分别为107和120 μ g/l （p = 0.06）。血浆硒水平第四个四分位数的人群发生结直肠腺瘤的风险是第一个四分位数人群的0.24倍（95%可信区间= 0.06-1.04）。血浆硒水平每增加30 μ g/l，结直肠腺瘤的校正优势比为0.58（95%可信区间= 0.31-1.08）。低血浆硒水平与多发腺瘤有关，但与腺瘤大小或位置无关。这些数据支持在排除可能的混杂因素后硒对结直肠腺瘤的保护作用。硒可能是一种潜在有用的结直肠肿瘤化学预防剂。
Previous research has suggested that selenium may protect against the development of colorectal neoplasia. We examined the potential chemopreventive properties of selenium against colorectal adenomas while controlling for a number of dietary and life-style factors. We conducted a cross-sectional study among patients referred for colonoscopy to University of North Carolina Hospitals. Cases had one or more pathologically confirmed adenomas, and noncases had none. Plasma selenium levels were determined using graphite furnace atomic absorption spectrometry with Zeeman background correction and platform technique. Odds ratios were calculated using logistic regression analysis adjusting for potential confounders. The mean plasma selenium concentrations for cases (n = 37) and noncases (n = 36) were 107 and 120 mu g/l, respectively (p = 0.06). Those in the fourth quartile of plasma selenium level had 0.24 times the risk (95% confidence interval = 0.06-1.04) for colorectal adenomas of those in the first quartile. The adjusted odds ratio for colorectal adenomas was 0.58 (95% confidence interval = 0.31-1.08) for a 30 mu g/l increase in plasma selenium level. Lower plasma selenium levels were associated with multiple adenomas but not with adenoma size or location. These data support a protective effect of selenium against colorectal adenomas after adjustment for possible confounders. Selenium might be a potentially useful chemo-preventive agent for colorectal neoplasia.