Effect of a high-cholesterol diet on lipoprotein metabolism and xanthoma formation in rabbits
Effect of a high-cholesterol diet on lipoprotein metabolism and xanthoma formation in rabbits
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DOI：
10.1111/jocd.12428
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发表时间：
2018-10-01
影响因子：
2.3
通讯作者：
Jiang, Hua
中科院分区：
文献类型：
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作者：
Hu, Hao;Gao, Yak;Jiang, Hua
背景黄斑瘤是最常见的皮肤黄瘤类型，通常发生在眼睑上。据报道，黄色瘤与脂蛋白代谢异常高度相关。目的在这项研究中，我们想要研究高胆固醇饮食对兔子黄色瘤形成和脂蛋白代谢的影响。方法在高胆固醇饮食喂养的动物中，检测血浆脂质[即总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（L-DLC）]水平和病理学黄色瘤。结果血浆脂质水平在 8 周内急剧升高。此外，高膳食胆固醇促进了颈背上黄色瘤的形成。显微镜检查显示，充满胆固醇沉积物的泡沫细胞积聚在真皮毛细血管和后颈皮肤内的皮肤附属器周围。结论这些发现表明高胆固醇饮食在兔脂蛋白代谢失调和黄瘤的发展中起着关键作用。结果提示，脂质代谢异常可能会增加黄色瘤的发生。
BackgroundXanthelasma is the most common type of cutaneous xanthoma and often occurs on the eyelids. Xanthoma has been reported to be highly correlated with abnormal lipoprotein metabolism.AimsIn this study, we wanted to investigate the effects of a high-cholesterol diet on xanthoma formation and lipoprotein metabolism in rabbits.MethodsIn animals fed with high-cholesterol diet, deteced plasma lipid [ie, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (L-DLC)] levels and pathology of xanthoma.ResultsPlasma lipid levels were dramatically elevated within 8 weeks. In addition, high dietary cholesterol promoted xanthoma formation on the napex. Microscopic examination showed that foam cells laden with cholesterol deposits accumulated around the dermal capillaries and cutaneous appendages within the skin of the napex.ConclusionThese findings indicate a critical role for a high-cholesterol diet in the dysregulation of lipoprotein metabolism and the development of xanthoma in rabbits. The results suggest that abnormal lipid metabolism may increase the occurrence of xanthoma.