A Quantitative Physiologic Model of Blood Oxygenation for Functional Magnetic Resonance Imaging
A Quantitative Physiologic Model of Blood Oxygenation for Functional Magnetic Resonance Imaging
复制标题
用于功能磁共振成像的血氧定量生理模型
DOI：
10.1097/00004424-199511000-00007
复制
发表时间：
1995
影响因子：
6.7
通讯作者：
R. Hawkins
中科院分区：
文献类型：
--
作者：
G. Hathout;S. Gambhir;Ramesh K. Gopi;K. Kirlew;Yong;G. So;D. Gozal;Ronald M. Harper;R. Lufkin;R. Hawkins
原理和说明。静脉脱氧血红蛋白水平响应神经元激活的变化代表了脑血流量（CBF）、脑血容量（CBV）和局部代谢的局灶性变化之间的复杂相互作用。作者提出了一个数学模型，描述了静脉氧合对这些变量变化的反应。方法：使用质量平衡方法，推导出一个简单的输入输出模型的方程，并使用Matlab求解。血氧的变化与功能性磁共振成像实验的结果有关。结果：根据Fick定律，CBF的增加导致氧提取分数和静脉脱氧血红蛋白的下降，并且与可用的磁共振和正电子发射断层扫描数据定量一致。流量包络线定义了CBF相对于CBV的变化。结论：有可能获得对血氧变化的定量理解，并将这些变化与功能刺激设置中观察到的磁共振信号变化的动力学联系起来。
RATIONALE AND OBJECTIVES. Variations in venous deoxyhemoglobin levels in response to neuronal activation represent a complex interplay between focal changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and regional metabolism. The authors present a mathematic model that characterizes the response of venous oxygenation to changes in these variables. METHODS.Using a mass balance approach, the equations for a simple input-output model are derived and solved using Matlab. Changes in blood oxygenation are related to available results from functional magnetic resonance imaging experiments. RESULTS.Increases in CBF produce declines in oxygen extraction fraction and venous deoxyhemoglobin according to Fick's law, and are quantitatively in agreement with available magnetic resonance and positron-emission tomography data. A flow-volume envelope defines the changes in CBF relative to CBV. CONCLUSIONS.It is possible to obtain a quantitative understanding of changes in blood oxygenation and to relate these changes to the observed dynamics of magnetic resonance signal change in the setting of functional stimulation.