Analysis of genetic admixture in Uyghur using the 26 Y-STR loci system.
Analysis of genetic admixture in Uyghur using the 26 Y-STR loci system.
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DOI：
10.1038/srep19998
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发表时间：
2016-02-04
影响因子：
4.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Bian Y;Zhang S;Zhou W;Zhao Q;Siqintuya;Zhu R;Wang Z;Gao Y;Hong J;Lu D;Li C
维吾尔族人口在历史上经历了与欧洲和东亚人口的广泛互动。一组高分辨率的遗传标记可能有助于推断维吾尔族人群与欧洲和亚洲人群之间的遗传关系。本研究对100名新疆南部维吾尔族男性进行了26个Y-STR基因座的分型。利用高分辨率的26个Y-STR基因座系统，我们研究了维吾尔族人群与23个欧洲或亚洲参考人群的遗传和系统发育关系。我们发现，维吾尔族人群表现出东亚和欧洲人群的遗传混合，并与选定的欧洲人群比东亚人群的关系略近。我们还表明，26个Y-STR基因座系统是潜在的有用的法医学，因为它具有很大的辨别力，很少表现出共同的单倍型。然而，由于人口的混合性质，维吾尔族样本的祖先推断可能具有挑战性。
The Uyghur population has experienced extensive interaction with European and Eastern Asian populations historically. A set of high-resolution genetic markers could be useful to infer the genetic relationships between the Uyghur population and European and Asian populations. In this study we typed 100 unrelated Uyghur males living in southern Xinjiang at 26 Y-STR loci. Using the high-resolution 26 Y-STR loci system, we investigated genetic and phylogenetic relationship between the Uyghur population and 23 reference European or Asian populations. We found that the Uyghur population exhibited a genetic admixture of Eastern Asian and European populations, and had a slightly closer relationship with the selected European populations than the Eastern Asian populations. We also demonstrated that the 26 Y-STR loci system was potentially useful in forensic sciences because it has a large power of discrimination and rarely exhibits common haplotypes. However, ancestry inference of Uyghur samples could be challenging due to the admixed nature of the population.