Patterns and scales in gastrointestinal microbial ecology.
Patterns and scales in gastrointestinal microbial ecology.
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DOI：
10.1053/j.gastro.2009.02.075
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发表时间：
2009-05
期刊：
影响因子：
29.4
通讯作者：
Rawls JF
中科院分区：
文献类型：
--
作者：
Camp JG;Kanther M;Semova I;Rawls JF
人类和其他动物的体表在出生时就被微生物定殖。人体上的大多数微生物存在于胃肠道群落中，它们对宿主生物学和病理学的许多方面做出了贡献。最近的技术进步增强了我们感知胃肠道微生物群落的成员和生理特征的能力。为了将这些信息转化为对宿主-微生物和微生物-微生物关系的机械和实际理解，有必要从生态学角度重新审视我们对胃肠道及其常驻微生物群落的概念。这篇综述在两个基本生态概念的背景下描述了胃肠道微生物生态学：（1）胃肠道内的生物多样性模式和（2）我们感知这些模式的时间、空间和环境尺度。我们展示了如何使用这个概念框架来整合我们现有的知识并确定胃肠道微生物生态学中重要的开放性问题。
The body surfaces of humans and other animals are colonized at birth by microorganisms. The majority of microbial residents on the human body exist within gastrointestinal (GI) tract communities, where they contribute to many aspects of host biology and pathobiology. Recent technological advances have expanded our ability to perceive the membership and physiologic traits of microbial communities along the GI tract. To translate this information into a mechanistic and practical understanding of host-microbe and microbe-microbe relationships, it is necessary to recast our conceptualization of the GI tract and its resident microbial communities in ecological terms. This review depicts GI microbial ecology in the context of 2 fundamental ecological concepts: (1) the patterns of biodiversity within the GI tract and (2) the scales of time, space, and environment within which we perceive those patterns. We show how this conceptual framework can be used to integrate our existing knowledge and identify important open questions in GI microbial ecology.