Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma
Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma
复制标题
三种六溴环十二烷非对映异构体对海洋青鳉胚胎的发育毒性
DOI：
10.1016/j.marpolbul.2015.11.009
复制
发表时间：
2015-12-15
影响因子：
5.8
通讯作者：
Shi, Dalin
中科院分区：
文献类型：
--
作者：
Hong, Haizheng;Shen, Rong;Shi, Dalin
海洋生物中主要的六溴环十二烷(HBCD)非对映异构体，即α-、β-和伽马-HBCD，其组成与被广泛用于毒理学研究的商业形式(工业HBCD)不同。为了正确评价HBCDs的影响，本研究以水稻胚胎为材料，研究了不同非对映异构体的发育毒性。结果表明，环境适宜浓度的HBCD非对映异构体在胚胎中可诱发畸形率和心跳，并导致心脏出现凋亡。此外，α-HBCDs、β-HBCDs和伽马-HBCDs具有相似的刺激活性氧产生的效力，从而导致黄褐斑潜蝇胚胎的细胞凋亡。α-、β-和γ-HBCDs在斑马鱼胚胎中的发育毒性顺序不同于先前研究的斑马鱼胚胎中的发育毒性，这突显了利用淡水和咸水中的物种进行毒性评估的重要性。(C)2015爱思唯尔有限公司。保留所有权利。
The composition of major hexabromocyclododecane (HBCD) diastereoisomers, i.e. alpha-, beta-, and gamma-HBCDs, in marine biota is different from that of the commercially available form (technical HBCD), which is used extensively for toxicological studies. To properly evaluate the impact of HBCDs, the embryos of Oryzias melastigma were used to examine the developmental toxicity of the individual diastereoisomers. Results showed that HBCD diastereoisomers at the environmentally realistic concentrations in the embryos induced malformation rate and heartbeat, and caused the appearance of apoptotic heart. In addition, alpha-, beta-, and gamma-HBCDs had similar potency to stimulate the generation of reactive oxygen species, consequently leading to apoptosis in O. melastigma embryos. The order of the developmental toxicity of alpha-, beta-, and gamma-HBCDs in O. melastigma embryos was different from that in zebrafish embryos studied previously, which highlighted the importance of using species from both fresh and salt water for toxicity assessment. (C) 2015 Elsevier Ltd. All rights reserved.