Global Burden of Thyroid Cancer From 1990 to 2017
Global Burden of Thyroid Cancer From 1990 to 2017
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DOI：
10.1001/jamanetworkopen.2020.8759
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发表时间：
2020-06-26
影响因子：
13.8
通讯作者：
Dai, ZhiJun
中科院分区：
文献类型：
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作者：
Deng, YuJiao;Li, HongTao;Dai, ZhiJun
本横断面研究根据地理位置、性别、年龄和社会经济指数，对甲状腺癌的全球时间趋势进行了研究。重要性甲状腺癌是全球最普遍的内分泌癌。研究甲状腺癌和国家之间的关联，性别，年龄，社会人口指数（SDI），和其他因素缺乏。目的利用性别、年龄和SDI数据，研究全球、区域和国家层面的甲状腺癌负担和变化趋势。在这项横断面研究中，使用全球健康数据交换查询工具收集流行病学数据，涵盖1990年1月1日至2017年12月31日期间195个国家和21个地区所有年龄段的甲状腺癌患者;数据分析于2019年10月1日完成。所有参与者都符合全球疾病负担研究的入选标准。主要结果和测量结果包括甲状腺癌的发病率、死亡率和残疾调整生命年（DADs）。测量按性别、地区、国家、年龄和SDI分层。计算估计的年百分比变化（EAPCs）和年龄标准化率，以评估时间趋势。结果甲状腺癌的发病率（169%）、死亡率（87%）和死亡率（75%）均呈上升趋势。标准化发病率（ASIR）随时间呈上升趋势，EAPC为1.59（95% CI，1.51-1.67）;年龄标准化死亡率（-0.15; 95% CI，-0.19至-0.12）和年龄标准化DALY率（-0.11; 95% CI，-0.15至-0.08）的EAPC有所下降。几乎一半（发病率41.73%，死亡率50.92%，残疾人54.39%）的甲状腺癌负担发生在南亚和东亚。此外，女性占甲状腺癌负担的大部分。（发病率为70.22%，死亡率为58.39%，DADs为58.68%），并且在该人群中逐年增加，尽管男性甲状腺癌患者的ASIR（EAPC，2.18; 95%CI，2.07-2.28）比女性（EAPC，1.38; 95%CI，1.30-1.46）增加更快。三分之一（34%）的甲状腺癌患者居住在SDI高的国家，大多数患者的年龄在50至69岁之间，这比其他五分之一人群的年龄大（SDI高的五分之一人群与所有其他五分之一人群相比，P
This cross-sectional study examines the worldwide temporal trends of thyroid cancer according to geographic location, sex, age, and socioeconomic index.Importance Thyroid cancer is the most pervasive endocrine cancer worldwide. Studies examining the association between thyroid cancer and country, sex, age, sociodemographic index (SDI), and other factors are lacking. Objective To examine the thyroid cancer burden and variation trends at the global, regional, and national levels using data on sex, age, and SDI. Design, Setting, and Participants In this cross-sectional study, epidemiologic data were gathered using the Global Health Data Exchange query tool, covering persons of all ages with thyroid cancer in 195 countries and 21 regions from January 1, 1990, to December 31, 2017; data analysis was completed on October 1, 2019. All participants met the Global Burden of Disease Study inclusion criteria. Main Outcomes and Measures Outcomes included incidence, deaths, and disability-adjusted life-years (DALYs) of thyroid cancer. Measures were stratified by sex, region, country, age, and SDI. The estimated annual percentage changes (EAPCs) and age-standardized rates were calculated to evaluate the temporal trends. Results Increases of thyroid cancer were noted in incident cases (169%), deaths (87%), and DALYs (75%). Age-standardized incidence rate (ASIR) showed an upward trend over time, with an EAPC of 1.59 (95% CI, 1.51-1.67); decreases were noted in EAPCs of age-standardized death rate (-0.15; 95% CI, -0.19 to -0.12) and age-standardized DALY rate (-0.11; 95% CI, -0.15 to -0.08). Almost half (41.73% for incidence, 50.92% for deaths, and 54.39% for DALYs) of the thyroid cancer burden was noted in Southern and Eastern Asia. In addition, females accounted for most of the thyroid cancer burden (70.22% for incidence, 58.39% for deaths, and 58.68% for DALYs) and increased by years in this population, although the ASIR of males with thyroid cancer (EAPC, 2.18; 95% CI, 2.07-2.28) increased faster than that of females (EAPC, 1.38; 95% CI, 1.30-1.46). A third (34%) of patients with thyroid cancer resided in countries with a high SDI, and most patients were aged 50 to 69 years, which was older than the age in other quintiles (high SDI quintile compared with all other quintiles, P