Duration of breastfeeding and risk of overweight: A meta-analysis
Duration of breastfeeding and risk of overweight: A meta-analysis
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DOI：
10.1093/aje/kwi222
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发表时间：
2005-09-01
影响因子：
5
通讯作者：
Plagemann, A
中科院分区：
文献类型：
--
作者：
Harder, T;Bergmann, R;Plagemann, A
观察性研究表明，较长的母乳喂养时间与晚年超重风险的降低呈剂量依赖性相关。作者对现有关于母乳喂养持续时间和超重风险的研究进行了全面的荟萃分析。纳入的研究报告了与母乳喂养相关的超重比值比和 95% 置信区间（或计算它们的数据），报告了母乳喂养的持续时间，并使用纯配方奶喂养的受试者作为参考。十七项研究符合纳入标准。通过荟萃回归，母乳喂养的持续时间与超重风险呈负相关（回归系数 = 0.94，95% 置信区间 (CI)：0.89、0.98）。分类分析证实了这种剂量反应关联（母乳喂养< 1个月：优势比（OR）= 1.0，95% CI：0.65，1.55；1-3个月：OR = 0.81，95% CI：0.74，0.88；4-6个月：OR = 0.76，95% CI：0.67，0.86； 7-9 个月：OR = 0.67，95% CI： 0.55、0.82； > 9 个月：OR = 0.68，95% CI：0.50、0.91)。母乳喂养 1 个月与风险降低 4% 相关（OR = 0.96/母乳喂养一个月，95% CI：0.94，0.98）。超重和年龄的定义没有影响。这些发现有力地支持了较长时间母乳喂养与降低超重风险之间存在剂量依赖性关联。
Observational studies suggest a longer duration of breastfeeding to be associated dose dependently with a decrease in risk of overweight in later life. The authors performed a comprehensive meta-analysis of the existing studies on duration of breastfeeding and risk of overweight. Studies were included that reported the odds ratio and 95% confidence interval (or the data to calculate them) of overweight associated with breastfeeding and that reported the duration of breastfeeding and used exclusively formula-fed subjects as the referent. Seventeen studies met the inclusion criteria. By meta-regression, the duration of breastfeeding was inversely associated with the risk of overweight (regression coefficient = 0.94, 95% confidence interval (CI): 0.89, 0.98). Categorical analysis confirmed this dose-response association (< 1 month of breastfeeding: odds ratio (OR) = 1.0, 95% CI: 0.65, 1.55; 1-3 months: OR = 0.81, 95% CI: 0.74, 0.88; 4-6 months: OR = 0.76, 95% CI: 0.67, 0.86; 7-9 months: OR = 0.67, 95% CI: 0.55, 0.82; > 9 months: OR = 0.68, 95% CI: 0.50, 0.91). One month of breastfeeding was associated with a 4% decrease in risk (OR = 0.96/month of breastfeeding, 95% CI: 0.94, 0.98). The definitions of overweight and age had no influence. These findings strongly support a dose-dependent association between longer duration of breastfeeding and decrease in risk of overweight.