Moisturizing lotions can increase transdermal absorption of the herbicide 2,4-dichlorophenoxacetic acid across hairless mouse skin
Moisturizing lotions can increase transdermal absorption of the herbicide 2,4-dichlorophenoxacetic acid across hairless mouse skin
复制标题
DOI：
10.1080/15569520601182791
复制
发表时间：
2007-01-01
影响因子：
1.6
通讯作者：
Jendrzejewski, J. L.
中科院分区：
文献类型：
--
作者：
Brand, R. M.;Charron, A. R.;Jendrzejewski, J. L.
保湿乳液可以有效治疗职业性皮肤干燥。这些化合物被设计成吸湿性的并保留水分以保持角质层水合，同时增强角质层以防止经表皮水分损失（TEWL）的增加。然而，已知皮肤水合水平会影响屏障性能。这项工作的目的是比较技能的水分水平诱导的四个市售保湿乳液与他们的能力作为透皮渗透促进剂使用除草剂2，4-二氯苯氧乙酸（2，4-D）作为模型化学品。此外，测定了用十二烷基硫酸钠（SLS）洗涤后的保湿效果对透皮吸收的影响。还以非侵入性方式测量了皮肤水分水平，并与渗透增强相关。无毛小鼠皮肤用市售保湿乳液预处理，用或不用SLS洗涤，并用除草剂2，4-D进行体外渗透性研究。数据表明，用四种测试洗剂中的三种进行预处理增加了2，4-D的透皮吸收，如累积渗透或更快的滞后时间所证明的（p < 0.05）。皮肤水分水平与洗剂的渗透增强能力相关。用5% SDS冲洗可促进2，4-D的透皮吸收（p < 0.05），使用保湿霜可进一步促进2，4-D的透皮吸收。总之，保湿乳液可以影响皮肤渗透的技能，更有效的保湿剂具有更大的效果油2，4-D吸收。
Moisturizing lotions can be an effective treatment for occupationally induced dry skin. These compounds are designed to be hygroscopic and retain water to keep the stratum corneum hydrated, while at the same time enhancing the horny layer to prevent increases in transepidermal water loss (TEWL). Skin hydration levels, however, are known to influence barrier properties. The purpose of this work was to compare skill moisture levels induced by four commercially available moisturizing lotions with their capacity as transdermal penetration enhancers using the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) as a model chemical. Further, the effect of moisturizing the skill after washing with sodium lauryl sulfate (SLS) on transdermal absorption was determined. Skin moisture levels were also measured noninvasively and were correlated to penetration enhancement. Hairless mouse skin was pretreated with commercially available moisturizing lotions either with or without SLS washing and in vitro permeability studies were performed with the herbicide 2,4-D. The data demonstrate that pretreatment with three of the four lotions tested increased the transdermal absorption of 2,4-D as evidenced by cumulative penetration or faster lag times (p < 0.05). Skin moisture levels correlated with the penetration enhancement capabilities of the lotion. Washing the skill with 5% SDS increased the transdermal absorption of 2,4-D (p < 0.05) and application of moisturizing lotions increased the absorption further. In summary moisturizing lotions may influence transdermal penetration of the skill, with the more effective moisturizers having a greater effect oil 2,4-D absorption.