Esophageal acid exposure at pH ≤ 2 is more common in Barrett's esophagus patients and is associated with oxidative stress
Esophageal acid exposure at pH ≤ 2 is more common in Barrett's esophagus patients and is associated with oxidative stress
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DOI：
10.1111/j.1442-2050.2006.00596.x
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Garewal, H.
中科院分区：
文献类型：
--
作者：
Dvorak, K.;Fass, R.;Garewal, H.
巴雷特食管 (BE) 患者比其他胃食管反流病患者表现出更高的远端食管酸暴露情况。细胞氧化应激被认为有助于 BE 和食管腺癌的发展。然而，低食管 pH 值与氧化应激之间的关系尚未阐明。本研究的目的是确定 BE 患者与糜烂性食管炎 (EE) 患者食管中低 pH 值暴露的持续时间，并测试短暂暴露于低 pH 值是否会导致活性氧 (ROS) 的诱导。通过 24 小时食管 pH 监测和暴露于 pH 值的时间百分比对 73 名 BE 或 EE 患者进行了评估
Barrett's esophagus (BE) patients demonstrate a higher distal esophageal acid exposure profile than other gastroesophageal reflux disease patients. Cellular oxidative stress has been proposed to contribute to the development of BE and esophageal adenocarcinoma. However, a relationship between low esophageal pH and oxidative stress has yet to be elucidated. The aim of this study was to determine the duration of low pH exposure in the esophagus of BE patients compared to those with erosive esophagitis (EE) and to test if brief exposure to low pH leads to the induction of reactive oxygen species (ROS).Seventy-three patients with BE or EE were evaluated by 24-hour esophageal pH monitoring and the percentage of time during which there was exposure to pH