Whole slide image data utilization informed by digital diagnosis patterns.
Whole slide image data utilization informed by digital diagnosis patterns.
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DOI：
10.1016/j.jpi.2022.100113
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发表时间：
2022
影响因子：
--
通讯作者：
Brown, J Quincy
中科院分区：
文献类型：
--
作者：
Ashman, Kimberly;Zhuge, Huimin;Shanley, Erin;Fox, Sharon;Halat, Shams;Sholl, Andrew;Summa, Brian;Brown, J Quincy
尽管数字病理有很多好处，但数字整张幻灯片图像的数据存储和管理给传统的模拟病理实验室带来了新的后勤和基础设施挑战。我们的目标是分析病理切片诊断模式，以确定诊断过程中所需的最小像素数。我们开发了一种方法，使用病理学家的观察模式来改变虚拟幻灯片上的数字图像分辨率，我们称之为可变分辨率图像。另一位病理学家检查了可变分辨率图像，以确定是否仍然可以进行诊断。在所有的幻灯片上，病理学家很少放大到全分辨率水平。因此，变分辨率图像明显小于原始的整个幻灯片图像。尽管图像尺寸减小，最终病理审稿人仍然可以对可变分辨率的幻灯片图像提供诊断。未来的研究将用于了解病理学家之间和内部分辨率要求的可变性。这些发现有可能显著降低高分辨率全幻灯片图像的数据存储要求。
Despite the benefits of digital pathology, data storage and management of digital whole slide images introduces new logistical and infrastructure challenges to traditionally analog pathology labs. Our goal was to analyze pathologist slide diagnosis patterns to determine the minimum number of pixels required during the diagnosis. We developed a method of using pathologist viewing patterns to vary digital image resolution across virtual slides, which we call variable resolution images. An additional pathologist reviewed the variable resolution images to determine if diagnoses could still be rendered. Across all slides, the pathologists rarely zoomed in to the full resolution level. As a result, the variable resolution images are significantly smaller than the original whole slide images. Despite the reduction in image sizes, the final pathologist reviewer could still proide diagnoses on the variable resolution slide images. Future studies will be conducted to understand variability in resolution requirements between and within pathologists. These findings have the potential to dramatically reduce the data storage requirements of high-resolution whole slide images.