Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines
Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines
复制标题
DOI：
10.1021/jacs.8b12689
复制
发表时间：
2019-02-27
影响因子：
15
通讯作者：
Bower, John F.
中科院分区：
文献类型：
--
作者：
Ma, Xiaofeng;Hazelden, Ian R.;Bower, John F.
用SPINOL衍生的氨基磷酸酯配体修饰的Pd（0）-体系促进N-（甲苯磺酰氧基）-氨基甲酸烯基酯的高度对映选择性的氮杂-Heck环化。该方法提供了具有挑战性的N-杂环的通用访问，并代表了迄今为止开发的最广泛的对映选择性氮杂-Heck协议。
Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantio-selective aza-Heck cyclizations of alkenyl N-(tosyloxy)-carbamates. The method provides versatile access to challenging N-heterocycles and represents the broadest scope enantioselective aza-Heck protocol developed to date.