Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release.
Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release.
复制标题
牙齿再生：牙齿发育和生物活性药物释放的时空控制的见解。
DOI：
10.1007/s1205-019-09940-0
复制
发表时间：
2020
影响因子：
4.8
通讯作者：
Zhou Chen
中科院分区：
文献类型：
--
作者：
Huang Delan;Ren Jianhan;Li Runze;Guan Chenyu;Feng Zhicai;Bao Baicheng;Wang Weicai;Zhou Chen
牙齿缺损和牙齿脱落是口腔临床常见疾病。与传统的口腔修复治疗相比，牙齿再生具有独特的优势，是目前口腔生物医学研究的热点。在牙齿发育过程中，数十种细胞因子/生长因子和其他生物活性因子的表达具有一定的时空规律。另一方面，近年来对药物释放时空控制技术的深入研究和发展，使得这些模拟时空模式的生物活性因子的控制释放在牙齿再生方面比以往任何时候都更加可行。本文综述了牙齿发育的研究进展，并在发育因子时空释放的背景下对牙齿再生的前景进行了展望。
Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.