Transmission of human-associated microbiota along family and social networks
Transmission of human-associated microbiota along family and social networks
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DOI：
10.1038/s41564-019-0409-6
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发表时间：
2019-06-01
影响因子：
28.3
通讯作者：
Alm, Eric J.
中科院分区：
文献类型：
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作者：
Brito, Ilana L.;Gurry, Thomas;Alm, Eric J.
人类微生物组由于其提供的关键功能而被描述为附属器官，由人类特有的物种组成（1，2）。然而，令人惊讶的是，人们对日常人际接触在塑造微生物组组成方面的影响知之甚少。在来自斐济群岛的287人的相对“封闭”队列中，没有常见的细菌传播障碍，我们使用来自核心单核苷酸多态性和灵活基因组区域的菌株水平数据检查了个人肠道和口腔微生物组中的假定细菌传播。我们发现了一个微弱的传播信号，由推断的基因型共享定义，在许多生物体中，总的来说，揭示了强烈的传播模式，最明显的是在家庭内部和配偶之间。我们无法确定传播的方向性，也无法确定是否是直接传播。我们进一步发现，女性携带的菌株与其家庭和社会接触者携带的菌株的关系比男性更密切，而且口腔相关和肠道相关微生物群的传播模式不一定相同。仅使用应变水平的数据，我们就能够自信地预测配偶的子集，突出共同的忠诚度，行为或社交互动的作用，以区分社交网络中的特定链接。
The human microbiome, described as an accessory organ because of the crucial functions it provides, is composed of species that are uniquely found in humans(1,2). Yet, surprisingly little is known about the impact of routine interpersonal contacts in shaping microbiome composition. In a relatively 'closed' cohort of 287 people from the Fiji Islands, where common barriers to bacterial transmission are absent, we examine putative bacterial transmission in individuals' gut and oral microbiomes using strain-level data from both core single-nucleotide polymorphisms and flexible genomic regions. We find a weak signal of transmission, defined by the inferred sharing of genotypes, across many organisms that, in aggregate, reveals strong transmission patterns, most notably within households and between spouses. We were unable to determine the directionality of transmission nor whether it was direct. We further find that women harbour strains more closely related to those harboured by their familial and social contacts than men, and that transmission patterns of oral-associated and gut-associated microbiota need not be the same. Using strain-level data alone, we are able to confidently predict a subset of spouses, highlighting the role of shared susceptibilities, behaviours or social interactions that distinguish specific links in the social network.