NUCLEOTIDE-SEQUENCES OF CLONED CDNAS FOR 2 TYPES OF BOVINE BRAIN SUBSTANCE-P PRECURSOR
NUCLEOTIDE-SEQUENCES OF CLONED CDNAS FOR 2 TYPES OF BOVINE BRAIN SUBSTANCE-P PRECURSOR
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DOI：
10.1038/306032a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
NAKANISHI, S
中科院分区：
文献类型：
--
作者：
NAWA, H;HIROSE, T;NAKANISHI, S
确定了两种牛脑物质P前体的一级结构。一种前体含有与两栖动物肽 kassinin 的序列同源的序列。这种新的速激肽序列由成对的碱性氨基酸 Lys-Arg 所限制，这表明它与 P 物质一样，可以从前体中释放出来，并可能在哺乳动物中充当内源性激素或神经介质。
The primary structures of 2 types of bovine brain substance P precursors were determined. One precursor contains a sequence homologous to that of the amphibian peptide kassinin. This new tachykinin sequence is bounded by paired basic amino acids Lys-Arg, which suggests that, like substance P, it can be liberated from the precursor and may serve as an endogenous hormone or neuromediator in mammalian organisms.