Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder.
Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder.
复制标题
日本自闭症谱系障碍儿童中抗博尔纳病病毒蛋白抗体的流行率。
DOI：
10.1111/1348-0421.12603
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Tomonaga K.
中科院分区：
文献类型：
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作者：
Honda T;Sofuku K;Matsunaga H;Tachibana M;Mohri I;Taniike M;Tomonaga K.
博尔纳病毒感染发生在包括人类在内的许多动物身上。然而，博尔纳病毒在人类，特别是儿童中的流行病学尚不清楚。在这里，我们用免疫荧光分析、免疫印迹和放射性配基试验评估了日本自闭症谱系障碍(ASD)儿童中的博尔纳病毒抗体。在ASD儿童中，针对博尔纳病毒特异性斑点、核蛋白和磷蛋白的抗体的流行率分别为22%、48%和33%。根据我们的标准，在ASD儿童中，博尔纳病毒抗体的流行率为7.4%。这是日本首次报告博尔纳病毒在儿童中的血清学流行情况。我们的结果为未来关于儿童博尔纳病毒流行病学的研究提供了有价值的基线数据。
Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus‐specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline‐data for future studies regarding bornavirus epidemiology in children.