Endothelial cell biology.
Endothelial cell biology.
复制标题
内皮细胞生物学。
作者：
J. Pearson
内皮不是用于容纳血细胞和血浆的被动血液相容性衬里，而是维持与血管稳态相关的广泛功能的代谢活性组织。本文综述了目前对内皮细胞生物学的分子和生化途径的理解。这些调节血管壁的凝血和血栓性质、血管张力，并因此调节血流和压力;在炎症和免疫应答产生期间溶质渗透性和白细胞运输的变化;以及最终调节血管生长和血管生成的过程。审查的结论与考虑如何这些功能特性可以被干扰，其可能的后果，在响应辐射，血管内造影剂，或血管成形术。
The endothelium is not a passive blood-compatible lining for the containment of blood cells and plasma, but rather it is a metabolically active tissue that subserves a wide range of functions relating to vascular homeostasis. This article reviews the current understanding of endothelial cell biology in terms of the molecules and biochemical pathways involved. These regulate coagulant and thrombotic properties of the vessel wall, vascular tone, and hence blood flow and pressure; changes in solute permeability and leukocyte traffic during the generation of inflammatory and immune responses; and finally the processes of vessel growth and angiogenesis. The review concludes with a consideration of how these functional properties can be disturbed, and their possible consequences, in response to irradiation, intravascular contrast media, or angioplasty.