Analytical prediction of hydrolysis behavior of tricalcium phosphate/ poly-L-lactic acid composites in simulated body environment
Analytical prediction of hydrolysis behavior of tricalcium phosphate/ poly-L-lactic acid composites in simulated body environment
复制标题
磷酸三钙/聚L-乳酸复合材料在模拟人体环境中水解行为的分析预测
DOI：
10.1080/09243046.2013.844902
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发表时间：
2014
影响因子：
2.9
通讯作者：
Satoshi KOBAYASHI and Shusaku Yamaji
中科院分区：
文献类型：
--
作者：
T.Ochiai;N.Takeuchi;S.Yoshida;O.Takeuchi;H.Shigekawa;Satoshi KOBAYASHI and Shusaku Yamaji
生物活性陶瓷/聚L乳酸复合材料有望成为一种生物相容性优于整体聚L乳酸的骨折内固定材料。本研究采用注射成型法制备了聚乳酸（PLLA）及β-磷酸三钙（β-TCP）含量为5、10、15wt%的PLLA/β-TCP复合材料，并研究了其在模拟人体环境中的水解行为。将样品浸入磷酸盐缓冲溶液中以测量样品的吸水率和分子量。整体PLLA的吸水率随着浸泡时间的增加而增加，直到14天，然后饱和，而复合材料的吸水率随着浸泡时间的增加而增加，直到168天。β-TCP含量越高，复合材料的吸水率越大。在相同的浸泡时间内，随着β-TCP含量的增加，复合材料的数均分子量降解速度加快。15重量%复合材料的数均分子量在24周浸泡后从60，000降低到39，000。提出了两层和三层模型分别预测吸水率和数均分子量变化。为了更准确地预测生物活性陶瓷/PLLA复合材料的水解行为，在所提出的模型中考虑了水扩散的影响。基于该模型的预测结果与实验结果吻合较好，证实了模型的有效性。
Bioactive ceramics/poly-L-lactic acid (PLLA) composites have been expected as a material for bone fracture fixations which have more biocompatibility than monolithic PLLA. In this study, monolithic PLLA and β-tricalcium phosphate (β-TCP)/PLLA composites containing three different β-TCP contents (5, 10, 15 wt%) were prepared by injection molding and hydrolysis behavior in simulated body environment was characterized. The specimens were immersed in phosphate buffered solution to measure water absorption and molecular weight of the specimen. Water absorption in monolithic PLLA increased with increasing immersion time up to 14 days, and then saturated, whereas water absorption in composites increased with increasing immersion time up to 168 days. The composites with higher β-TCP content showed larger water absorption. Degradation of number averaged molecular weight for the composites became faster with β-TCP content at the same immersion time. Number averaged molecular weight of 15 wt% composites decreased from 60,000 to 39,000 after 24 weeks immersion. Two layers and three layers models were proposed to predict water absorption and number average molecular weight variation, respectively. To predict hydrolysis behavior of bioactive ceramics/PLLA composites more precisely, effect of water diffusion was considered in the proposed models. Predictions based on the present models were in good agreement with experimental results and the effectiveness of the models was confirmed.