Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia
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DOI：
10.1016/s0198-8859(02)00423-8
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发表时间：
2002-09-01
期刊：
影响因子：
2.7
通讯作者：
Casato, M
中科院分区：
文献类型：
--
作者：
De Rosa, FG;Pucillo, LP;Casato, M
有研究表明，丙型肝炎病毒感染的II型混合冷球蛋白血症患者比无冷球蛋白血症的患者肝损害范围小。我们回顾评估了35例合并丙型肝炎病毒感染的II型混合冷球蛋白血症患者，寻找与丙氨酸氨基转移酶(ALT)正常值相关的因素。抗GOR和其他自身抗体的存在，包括最近描述的抗LAG-3.1，进行了专门的调查。抗GOR抗体阳性率为54%，抗LAG-3.1抗体阳性率为46%，抗平滑肌抗体阳性率为40%，抗核抗体阳性率为17%，抗肝肾微粒子1抗体阳性率为11%。抗GOR与抗LAG-3.1显著相关(p=0.037)，而与其他自身抗体无关。54%的患者ALT水平持续异常。单因素分析显示，ALT异常与抗-GOR阳性(p=0.018.0 5)和年龄偏小(p=0.0 3)显著相关。多因素回归分析证实，这些变量与ALT异常独立相关。我们的数据表明，自身免疫表现和不明年龄相关宿主因子(S)的存在可能对丙型肝炎病毒相关性冷球蛋白血症的肝损伤具有保护作用。(C)美国组织相容性和免疫遗传学会，2002年。爱思唯尔科学公司出版。
It has been suggested that hepatitis C virus (HCV) infected patients with type II mixed cryoglobulinemia have less extensive liver damage than patients without cryoglobulinemia. We retrospectively evaluated 35 patients with type II mixed cryoglobulinemia associated with HCV infection, seeking for factors associated with normal alanine aminotransferase (ALT) values. The presence of anti-GOR and of other autoantibodies, including the recently described anti-LAG-3.1, was specifically investigated. Fifty-four percent of patients had anti-GOR, 46% anti-LAG-3.1, 40% anti-smooth muscle, 17% antinuclear, and 11% anti-liver-kidney microsome 1 antibodies. Anti-GOR was significantly (p = 0.037) associated with anti-LAG-3.1 but not with other autoantibodies. Persistently abnormal ALT levels were observed in 54% of patients. By univariate analyses, abnormal ALT was significantly associated with anti-GOR positivity (p = 0.018) and younger age (p = 0.03). Multivariate regression analysis confirmed that these variables were independently associated with abnormal ALT. Our data suggest that the presence of autoimmune manifestations as well as unidentified age-related host factor(s) may protect from liver injury in HCV-associated cryoglobulinemia. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.