The risk of COVID-19 for pregnant women: Evidences of molecular alterations associated with preeclampsia in SARS-CoV-2 infection.
The risk of COVID-19 for pregnant women: Evidences of molecular alterations associated with preeclampsia in SARS-CoV-2 infection.
复制标题
COVID-19对孕妇的风险：SARS-CoV-2感染中与先兆子痫相关的分子改变的证据。
DOI：
10.1016/j.bbadis.2020.165999
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发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Berger M
中科院分区：
文献类型：
--
作者：
Beys-da-Silva WO;da Rosa RL;Santi L;Tureta EF;Terraciano PB;Guimarães JA;Passos EP;Berger M
孕妇及其婴儿是当前冠状病毒病（COVID-19）大流行期间需要特别关注的最脆弱人群[1]。感染是由一种新的包膜RNA β-冠状病毒引起的，即严重急性呼吸综合征冠状病毒-2（SARS-CoV-2），它主要通过与特异性受体血管紧张素转换酶-2（ACE-2）结合感染肺的II型肺泡上皮细胞[2]。由于ACE-2在不同组织中广泛表达，因此心脏、血管、肾脏、肠、脑和胎盘等肺外部位均可受到病毒的影响[3]。众所周知，妊娠期间的生理和免疫变化可掩盖甚至增加呼吸道感染的易感性。变化包括心率增加、肺容量改变以及自然生理转变为辅助性T细胞2应答（Th 2），其通过Th 1系统减弱细胞介导的免疫力，使母亲易受病毒感染[1]。事实上，在流感病毒和其他两种冠状病毒株（严重急性呼吸系统综合征（SARS）和中东呼吸系统综合征（MERS））引起的疫情期间，已经证明了与非孕妇相比，孕产妇发病率和死亡率风险增加的不良后果[4]。
Pregnant women and their infants are among the most vulnerable populations requiring special attention during the current Coronavirus disease (COVID-19) pandemic [1]. The infection is caused by a new enveloped RNA β-coronavirus, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which can primarily infect type II alveolar epithelial cells of the lung through the binding to a specific receptor, angiotensin converting enzyme-2 (ACE-2)[2]. Since ACE-2 is widely expressed in different tissues, several extrapulmonary sites, such as heart, blood vessels, kidney, intestine, brain and placenta can be affected by the virus [3].It is well known that physiological and immunological changes during pregnancy can mask or even increase the susceptibility to respiratory infections. Changes including increased heart rate, altered pulmonary volumes, as well as the natural physiological shift to a T-helper 2 response (Th2) which attenuates the cell-mediated immunity by Th1 system, leaving the mother vulnerable to viral infections [1]. In fact, adverse outcomes showing increased risk of maternal morbidity and mortality when compared to non-pregnant women have been demonstrated during the outbreaks caused by influenza virus and also other two coronavirus strains, the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS)[4].
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影响因子：
14.9
作者：
Rappaport N;Twik M;Plaschkes I;Nudel R;Iny Stein T;Levitt J;Gershoni M;Morrey CP;Safran M;Lancet D
通讯作者：
Lancet D
DOI：
10.1111/1471-0528.16339
发表时间：
2020-06-21
影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
D'Eustachio P
与 ACE2 受体结合的 SARS-CoV-2 刺突受体结合域的结构
影响因子：
64.8
作者：
Lan, Jun;Ge, Jiwan;Wang, Xinquan
通讯作者：
Wang, Xinquan