Drug-Induced Hyperthermic Syndromes Part I. Hyperthermia in Overdose
Drug-Induced Hyperthermic Syndromes Part I. Hyperthermia in Overdose
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DOI：
10.1016/j.emc.2013.07.004
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发表时间：
2013-11-01
影响因子：
1.2
通讯作者：
Barrueto, Fermin, Jr.
中科院分区：
文献类型：
--
作者：
Hayes, Bryan D.;Martinez, Joseph P.;Barrueto, Fermin, Jr.
当过量使用时，影响体温调节系统的药物和天然化合物可能会诱发或导致体温过高。与药物过量相关的体温过高是危险的，可能是致命的。本文综述了人体维持热力学平衡的过程，并描述了交感神经和抗胆碱能药物、水杨酸盐和甲状腺替代药物对其影响的机制。讨论了适当的治疗策略，如降温和给予对抗活性药物。
Drugs and natural compounds that affect the thermoregulatory system can induce or contribute to hyperthermia when used in excess. Hyperthermia associated with drug overdose is dangerous and potentially lethal. This article reviews the body's process of maintaining thermodynamic equilibrium, and describes the mechanisms by which it is influenced by sympathomimetic and anticholinergic drugs, salicylates, and thyroid replacement medications. Appropriate treatment strategies such as cooling and the administration of counteractive medications are discussed.