Differential expression of transthyretin in papillary tumors of the endolymphatic sac and choroid plexus
Differential expression of transthyretin in papillary tumors of the endolymphatic sac and choroid plexus
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DOI：
10.1097/00005537-199702000-00014
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发表时间：
1997-02-01
期刊：
影响因子：
2.6
通讯作者：
McKenna, MJ
中科院分区：
文献类型：
--
作者：
Megerian, CA;Pilch, BZ;McKenna, MJ
颞骨侵袭性乳头状肿瘤，偶发或作为von Hippel-Lindau病的一部分发生，已被证明起源于内淋巴囊或导管内。异位脉络丛上皮也被认为是这些肿瘤可能起源的潜在前体。为了帮助区分内淋巴囊和导管起源的乳头状肿瘤和脉络丛起源的乳头状肿瘤，用甲状腺素运载蛋白（TTR）、细胞角蛋白、S-100蛋白、上皮膜抗原（EMA）和胶质细胞酸性蛋白（GFAP）的染色对正常人的存档标本进行免疫组织化学研究。肿瘤性内淋巴囊、内淋巴管和脉络丛上皮。甲状腺素运载蛋白是脉络丛上皮细胞的标志物，在脉络丛乳头状瘤和侵袭性内淋巴管乳头状瘤中有不同的表达。因此，TTR与其他免疫组化染色的配合使用似乎有助于区分颅内和颞内乳头状肿瘤起源于脉络丛和内淋巴囊或导管上皮。
Aggressive papillary tumors of the temporal bone, occurring sporadically or as part of von Hippel-Lindau disease, have been shown to originate within the endolymphatic sac or duct, Also implicated as a potential precursor from which some of these tumors may arise is ectopic choroid plexus epithelium, To aid in the differentiation between papillary tumors of endolymphatic sac and duct origin and those arising from choroid plexus, an immunohistochemical study using stains for transthyretin (TTR), cytokeratins, S-100 protein, epithelial membrane antigen (EMA), and glial fibrillary acidic protein (GFAP) was carried out on archival specimens of normal. and neoplastic endolymphatic sac and duct and choroid plexus epithelium. Transthyretin, a mark er for choroid plexus epithelium, was found to show differential expression between choroid plexus papillomas and aggressive papillary tumors of the endolymphatic sec or duct. Therefore the use of TTR in concert with other immunohistochemical stains appear to aid in the differentiation between intracranial and intratemporal papillary tumors arising from choroid plexus and endolymphatic sac or duct epithelium.