An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.
An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.
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来自培养的蓝藻 Scytonema sp 的抗菌含胍双倍萜。
DOI：
10.1021/np900288x
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发表时间：
2009
影响因子：
5.1
通讯作者：
Orjala,Jimmy
中科院分区：
文献类型：
--
作者：
Mo,Shunyan;Krunic,Aleksej;Pegan,ScottD;Franzblau,ScottG;Orjala,Jimmy
Scytoscalarol(1)是从培养的蓝藻细菌Scytoscalarol(1)中分离到的一种含有胍基的抗菌酯萜。（UTEX 1163）通过生物测定引导分离。化学结构通过质谱、一维和二维核磁共振等光谱分析确定。Scytoscalarol(1)对炭疽芽孢杆菌、金黄色葡萄球菌、大肠杆菌、白色念珠菌和结核分枝杆菌具有抑菌活性，MIC值在2 ~ 110 μM之间。
Scytoscalarol (1), a antimicrobial sesterterpene bearing a guanidino group, was isolated from the cultured cyanobacteriumScytonemasp. (UTEX 1163) by bioassay-guided fractionation. The chemical structure was determined by spectroscopic analysis including MS and 1D and 2D NMR. Scytoscalarol (1) showed antimicrobial activities againstBacillus anthracis,Staphylococcus aureus,Escherichia coli,Candida albicans, andMycobacterium tuberculosiswith MIC values in the range from 2 to 110 μM.