Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.
Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.
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次级淋巴器官的细胞外基质影响 B 细胞的命运和存活。
DOI：
10.1073/pnas.1218131110
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发表时间：
2013
影响因子：
11.1
通讯作者：
Cardell,Su
中科院分区：
文献类型：
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作者：
Song,Jian;Lokmic,Zerina;Lämmermann,Tim;Rolf,Julia;Wu,Chuan;Zhang,Xueli;Hallmann,Rupert;Hannocks,Melanie-Jane;Horn,Nathalie;Ruegg,MarkusA;Sonnenberg,Arnoud;Georges-Labouesse,Elisabeth;Winkler,ThomasH;Kearney,JohnF;Cardell,Su
我们描述了脾脏中独特的细胞外基质（ECM）小生境，边缘区（MZ），其特征在于基底膜糖蛋白、层粘连蛋白α 5和聚集蛋白，其促进了MZ B淋巴细胞的特化群体的形成，所述淋巴细胞对血源性抗原快速反应。层粘连蛋白α 5表达减少的小鼠显示MZ B细胞减少，从骨髓迁移的新形成（NF）过渡性B细胞数量增加，而其他免疫或基质细胞区室无变化。MZ中NF B细胞与层粘连蛋白α 5的瞬时整合素α 6 β 1介导的相互作用支持MZ B细胞群、其长期存活和抗体应答。数据表明，淋巴器官ECM的独特3D结构和生化组成影响免疫细胞的命运。
We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.