Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease
Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease
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DOI：
10.1006/nbdi.1998.0203
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发表时间：
1998-11-01
影响因子：
6.1
通讯作者：
Vickers, JC
中科院分区：
文献类型：
--
作者：
Adlard, PA;West, AK;Vickers, JC
我们研究了金属硫蛋白VII（MT MR）在阿尔茨海默病（AD）中的可能作用，重点是MT MI相对于星形胶质细胞标记物胶质细胞酸性蛋白（GFAP）的细胞定位。在AD和临床前AD病例中，MT I/II免疫标记存在于神经胶质细胞中，并没有显示与P-淀粉样蛋白斑块或神经病理学的空间关系。有一个六至七倍的增加，NIT I/II-和GFAP-标记的细胞在灰质的AD病例，相对于非AD病例。然而，有三倍增加MT I/II-免疫反应细胞，但不是GFAP标记的细胞，在临床前AD病例的灰质相比，非AD病例。因此，MT I/II的特定增加与疾病过程的初始阶段相关，可能是由于氧化应激或重金属的代谢不良。(C)北京：科学出版社.
We have examined the possible role of metallothionein VII (MT mr) in Alzheimer's disease (AD), with a focus on the cellular localization of MT mi relative to the astrocyte marker, glial fibrillary acidic protein (GFAP). In AD and preclinical AD cases, MT I/II immunolabeling was present in glial cells and did not show a spatial relationship with P-amyloid plaques or neurofibrillary pathology. There was a six- to sevenfold increase in both NIT I/II- and GFAP-labeled cells in the gray matter of AD cases, relative to non-AD cases. However, there was a threefold increase in MT I/II-immunoreactive cells, but not GFAP-labeled cells, in the gray matter of preclinical AD cases compared to non-AD cases. Therefore, the specific increase in MT I/II is associated with the initial stages of the disease process, perhaps due to oxidative stress or the mismetabolism of heavy metals. (C) 1998 Academic Press.