Novel immunoregulatory properties of EGCG on reducing inflammation in EAE
Novel immunoregulatory properties of EGCG on reducing inflammation in EAE
复制标题
EGCG 在减少 EAE 炎症方面的新免疫调节特性。
DOI：
10.2741/4104
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发表时间：
2013-01-01
影响因子：
3.1
通讯作者：
Nie, Hong
中科院分区：
文献类型：
--
作者：
Sun, Quanye;Zheng, Yingxia;Nie, Hong
表没食子儿茶素没食子酸酯是绿色茶中的主要儿茶素之一。本研究旨在探讨表没食子儿茶素没食子酸酯（EGCG）改善实验性自身免疫性脑脊髓炎（EAE）的新调控机制。数据显示，EGCG通过减少脑炎症和脱髓鞘损伤，伴随着降低致脑炎性T细胞反应和减少炎性细胞因子和趋化因子的表达，降低了EAE的疾病严重程度。表没食子儿茶素没食子酸酯的作用是由于其选择性抑制干扰素-γ和白细胞介素-17在CD 4 + T细胞的生产，通过改变STAT途径和转录因子T-bet和维甲酸相关孤儿受体（ROR）γ/ROR α介导。更重要的是，本研究发现EGCG具有直接抑制Th 1和Th 17细胞分化的新特性。另一方面，EGCG处理的抗原呈递细胞（APC）表现出减少的共刺激功能，作为改变CD 80和CD 86的表达的结果。本研究的结果表明，EGCG是一种新型的抗炎剂，可以作为一个有用的药物治疗多发性硬化症和其他神经炎症性疾病的进一步。
EGCG is one of the major catechins in green tea. In this study, we investigated the novel regulatory mechanism of EGCG on amelioration of experimental autoimmune encephalomyelitis (EAE). The data showed that EGCG reduced disease severity in EAE by decreasing brain inflammation and demyelination damage, accompanied by decreased encephalitogenic T cell responses and reduced expression of inflammatory cytokines and chemokines. The effect of EGCG was attributable to its selective inhibition of interferon-gamma and interleukin-17 production in CD4+ T cells, mediated via alteration of the STAT pathway and the transcription factors T-bet and retinoid-related orphan receptor (ROR) gammat/ROR alpha. More important, EGCG has been found novel properties of directly inhibiting Th1 and Th17 cell differentiation in this study. On the other hand, EGCG-treated antigen presenting cells (APC) exhibited reduced co-stimulatory function as a result of altered expression of CD80 and CD86. The results of this study indicate that EGCG is a novel anti-inflammatory agent that could act as a useful drug for the treatment of multiple sclerosis and other neuroinflammatory diseases in the further.