Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
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DOI：
10.1136/gut.2003.022061
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发表时间：
2004-06-01
期刊：
影响因子：
24.5
通讯作者：
Caldas, C
中科院分区：
文献类型：
--
作者：
Fitzgerald, RC;Caldas, C
大约1-3%的胃癌是由遗传性胃癌易感综合征引起的。这些可能是弥漫性或肠型。连锁分析最近牵连E-cadherin基因突变，估计25%的家庭与常染色体显性遗传倾向弥漫型胃癌。这种胃癌被称为遗传性弥漫性胃癌（HDGC）。
Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).