Gender differences in electrical remodeling and susceptibility to ventricular arrhythmias in rabbits with left ventricular hypertrophy
Gender differences in electrical remodeling and susceptibility to ventricular arrhythmias in rabbits with left ventricular hypertrophy
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DOI：
10.1016/j.hrthm.2006.03.010
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发表时间：
2006-07-01
期刊：
影响因子：
5.5
通讯作者：
Quinteiro, Ricardo A.
中科院分区：
文献类型：
--
作者：
Biagetti, Marcelo O.;Quinteiro, Ricardo A.
背景左心室肥厚（LVH）与死亡风险增加、易发生室性心律失常、目的本研究的目的是确定性别-在肾血管性高血压家兔模型中，电重构和室性心律失常易感性的依赖性差异。肾切除术或置于对照组。结果左室肥厚组动作电位时程较对照组延长，左室肥厚组动作电位时程较对照组延长。（对照组[n=5]和LVH家兔动作电位时程[APD]（90 Epi）和APD（90 Endo）分别为123 +/- 2.4 ms和151 +/- 2.3 ms与180 +/- 5.1 ms和196 +/- 3.1 ms）。n=8]; P
Background Left ventricular hypertrophy (LVH) is associated with an increased risk of death, vulnerability to ventricular arrhythmia, and multiple electrophysiological abnormalities.Objectives The purpose of the present study was to determine the gender-dependent differences in electrical remodeling and the susceptibility to ventricular arrhythmias in a rabbit model of renovascular hypertension.Methods Rabbits of both sexes underwent unilateral renal artery banding and contralateral nephrectomy or were placed in the control group. Data are expressed as mean +/- standard error of the mean.Results The duration of action potentials was prolonged in the LVH group compared with the control group in both mate (123 +/- 2.4 ms and 151 +/- 2.3 ms vs. 180 +/- 5.1 ms and 196 +/- 3.1 ms for action potential duration [APD](90 Epi) and APD(90 Endo) of control [n=5] and LVH rabbits [n=8], respectively; P