IMPROVED 72-HOUR RENAL PRESERVATION WITH PHOSPHATE-BUFFERED SUCROSE
IMPROVED 72-HOUR RENAL PRESERVATION WITH PHOSPHATE-BUFFERED SUCROSE
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DOI：
10.1097/00007890-198905000-00003
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发表时间：
1989-05-01
期刊：
影响因子：
6.2
通讯作者：
GILES, GR
中科院分区：
文献类型：
--
作者：
LAM, FT;MAVOR, AID;GILES, GR
本研究的结果表明，一个简单的磷酸盐缓冲蔗糖溶液（PBS）比高渗性柠檬酸盐（HOC）溶液在冲洗灌注和低温保存犬肾72小时，然后自体移植立即对侧肾切除。术中测量再灌注后肾血流量显示，HOC溶液保存的肾脏在60分钟后显著减少。PBS组中所有移植物和动物（5/5）均存活，并具有原发性肾功能，而HOC组中只有一个移植物和动物（1/5）在少尿期后仍有功能。PBS组的早期血清肌酐和尿素水平显著降低，两周内恢复正常范围。这反映在PBS动物中更高的菊粉清除率和更快的近端肾小管功能恢复，这也证明了袢功能和浓缩尿液的能力的更快恢复。
The result of this study shows that a simple phosphate buffered sucrose solution (PBS) is better than hyperosmolar citrate (HOC) solution in the flush perfusion and hypothermic storage of canine kidneys for 72 hr prior to autotransplantation with immediate contralateral nephrectomy. The peroperative measurement of postreperfusion renal blood flow revealed a significant reduction after 60 min in kidneys preserved with HOC solution. All grafts and animals in the PBS group (5/5) survived with primary renal function compared with one of the HOC group (1/5), which functioned after a period of oliguria. The early serum creatinine and urea levels were significantly lower in the PBS group, with a return to normal range within two weeks. This is reflected in higher inulin clearances and a more rapid recovery of proximal tubular function in the PBS animals, which also demonstrated a more rapid return of loop function and the ability to concentrate urine.