Early life exposure to poor nutrition and infectious diseases and its effects on the health of older Puerto Rican adults.
Early life exposure to poor nutrition and infectious diseases and its effects on the health of older Puerto Rican adults.
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DOI：
10.1093/geronb/63.6.s337
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Gurucharri AG
中科院分区：
文献类型：
--
作者：
McEniry M;Palloni A;Dávila AL;Gurucharri AG
我们以出生季节为指标，研究了早期接触营养不良和传染病对成人心脏病和糖尿病的影响，以帮助区分早期暴露对健康的影响与与其他儿童状况相关的影响。利用60至74岁的波多黎各人童年时期生活在农村地区的数据(n=1,457)，我们估计了妊娠晚期季节性暴露对糖尿病和心脏病的概率的影响，控制了成人肥胖和其他儿童状况(健康、社会经济状况、膝盖高度)。我们发现(A)暴露与心脏病之间有很强的相关性；(B)暴露与糖尿病之间的联系较弱，尽管暴露与患有糖尿病的家庭成员之间的显著负面交互影响表明，可能存在强烈的基因-环境或早期成人-环境交互作用；(C)自我报告的童年健康与暴露对照的影响几乎没有减弱。出生的时间可能揭示了围产期经历的影响成人心脏病和糖尿病的疾病。结果表明，在波多黎各老年人和来自类似人口的老年人中，出生季节对这些慢性病的影响值得进行更深入的审查。
We examined the effects of early life exposure to poor nutrition and infectious diseases on adult heart disease and diabetes using season of birth as an indicator to help disentangle the effects on health of early life exposure from effects associated with other childhood conditions. Using data from 60- to 74-year-old Puerto Ricans who lived in rural areas during childhood (n = 1,457), we estimated the effects of seasonal exposure during late gestation on the probability of diabetes and heart disease, controlling for adult obesity and other childhood conditions (health, socioeconomic status, knee height). We found (a) strong associations between exposure and heart disease; (b) weaker associations between exposure and diabetes, although significant negative interaction effects between exposure and having a family member with diabetes suggest the possibility of either strong gene–environment or early adult–environment interactions; (c) virtually no attenuation of effects of self-reported childhood health with controls for exposure. Timing of birth may reveal conditions experienced perinatally that affect adult heart disease and diabetes. The results suggest that examination of the effects of season of birth on these chronic conditions among older Puerto Rican adults and among older adults from similar populations deserves deeper scrutiny.
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影响因子：
2.4
作者：
JOHN, AM;MENKEN, JA;CHOWDHURY, AKMA
通讯作者：
CHOWDHURY, AKMA
DOI：
10.1093/geronb/60.special_issue_2.s117
发表时间：
2005-10-01
影响因子：
6.2
作者：
O'Rand, AM;Hamil-Luker, J
通讯作者：
Hamil-Luker, J
DOI：
10.1016/0160-8002(79)90042-x
发表时间：
1979-01-01
期刊：
SOCIAL SCIENCE & MEDICINE PART D-MEDICAL GEOGRAPHY
影响因子：
--
作者：
KEVAN, SM
通讯作者：
KEVAN, SM
影响因子：
3.5
作者：
Haas, Steven A.
通讯作者：
Haas, Steven A.
影响因子：
12.7
作者：
BECERRA, JE;SMITH, JC
通讯作者：
SMITH, JC