Serotonin and aversive processing in affective and social decision-making
Serotonin and aversive processing in affective and social decision-making
复制标题
DOI：
10.1016/j.cobeha.2015.08.005
复制
发表时间：
2015-10-01
影响因子：
5
通讯作者：
Cools, R.
中科院分区：
文献类型：
--
作者：
Crockett, M. J.;Cools, R.
神经调节剂血清素对情感和行为的影响是如此多样和广泛，以至于表征其功能面临着巨大的挑战。在这里，我们回顾了最近的工作，调查如何血清素形状的情感和社会决策在人类，特别是集中在血清素的影响厌恶处理。我们认为，血清素在连接所谓的巴甫洛夫厌恶性预测与行为抑制，一个来自基于价值的决策的计算模型的建议，发挥了关键作用的证据。我们评估了将血清素与巴甫洛夫抑制联系起来的核心机制在多大程度上可以解释血清素对情感和社会决策的不同影响，并强调了未来研究的关键问题。
The effects of the neuromodulator serotonin on affect and behavior are so diverse and wide-ranging that characterizing its function has faced substantial challenges. Here we review recent work investigating how serotonin shapes affective and social decision-making in humans, focusing in particular on serotonin's influence on aversive processing. We consider the evidence that serotonin plays a key role in linking so-called Pavlovian aversive predictions with behavioral inhibition, a proposal derived from computational models of value-based decision-making. We evaluate the extent to which a core mechanism connecting serotonin with Pavlovian inhibition can explain diverse effects of serotonin on affective and social decision-making and highlight critical questions for future research.