The possible role of insulin-like growth factor-1 in osteosarcoma
The possible role of insulin-like growth factor-1 in osteosarcoma
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DOI：
10.1016/j.currproblcancer.2018.08.008
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发表时间：
2019-06-01
影响因子：
2.6
通讯作者：
Luo, Wei
中科院分区：
文献类型：
--
作者：
Li, Yu-sheng;Liu, Qing;Luo, Wei
Osteosarcoma (OS) is a common malignant tumor of bone, of which clear understanding of molecular pathologic process is not yet possible. Insulin-like growth factor-1 (IGF-1) is a hormone that plays vital role in development and function of many tissues. Unfortunately, IGF-1 and its receptor (IGF-1R)'s over-expression have been implicated in carcinogenesis, and indicated to constitute a risk factor for the development of multiple human cancers, including OS. Increased levels of IGF-1 and IGF-1R have been reported in OS, leading to cancer progression through transformation, proliferation, pro-metastasis, and decreased susceptibility to apoptosis. Over-expression of IGF-1/IGF-1R signaling also contributes to tumor cell survival, metastasis, and resistance to chemotherapeutic drugs. IGF-1 has been included as an OS marker recently, and targeting IGF-1 is an interesting and promising approach in OS therapeutics. However more investigations with clinical trials are necessary to validate the use of drugs against IGF-1 that may provide a basis for new therapeutic approaches to treat this devastating disease. This review article focused on the role of IGF-1 /IGF-1R in OS progression and therapeutic aspects of OS targeting IGF-1. (C) 2018 Elsevier Inc. All rights reserved.
